DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B3 and Ugt35B1

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_524313.2	Gene:	Ugt35B1 / 41333	FlyBaseID:	FBgn0026314	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	506	Identity:	175/506 - (34%)
Similarity:	285/506 - (56%)	Gaps:	21/506 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVGMPTDIEGVRHIRVPKLNQRVQE 88
            |:|||.||.||.:...|..:.|.|..|.|..|||.||.:........:...|.:.:|.:....:|
  Fly    16 SMQAARILAIFPFPGPSQYINVVPYLKELANRGHQVTSVNAFPQKKPVVNFRDVFIPDVFNNYKE 80

  Fly    89 MIEGDQILDFFG--SKWIASLMVVSMLYNMSSDILSDKGV-QKMLQNRNERFDLVMLEPSALEAL 150
            :|.     :..|  :.|..:..:.....:::..:|::|.| :.:|....:.|||:::|....:|.
  Fly    81 LIN-----ELSGPMNLWQENNFINKFFVSVTRCVLTNKEVTETLLPPGKDHFDLIIVEALRSDAY 140

  Fly   151 YGVVEHYNATLMGFSGGNVNWSTEEVAGNFAPSINDPISSLGYSRSNSLLSKIYNWVHITEEKLL 215
            ||...|:||.::|.|....:|:.:.:.||.:|....|:::.|.:...:.|.::.|:|..|...|.
  Fly   141 YGFAAHFNAPIIGISTFGTDWNIDALVGNESPLSYTPLATGGLTDRMTFLERLSNFVDTTVAWLN 205

  Fly   216 KHLIFRPSQLRIFKKFFNFSEQK--FYNMREKYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEP 278
            ...:....|.:::.|:|..:.::  ..::...:|::|:|.|.|:...|..|||:|||||||::..
  Fly   206 YRFVHMSEQEKMYAKYFPEASKRVQLTDLNRNFSLVLLNQHFSLSFPRPYVPNMIEVGGLHISHK 270

  Fly   279 AEPCDSKLQKFMD-DAEHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMPNK 342
            ..|....|::|:. ..||||||||:|..::.:.||.|.:..::|:.....|||:||.|...:|.|
  Fly   271 PAPLPKDLEEFIQGSGEHGVIYFSLGSNVLSKDLPADRKDLILKTFASLPQRVLWKFEDDKLPGK 335

  Fly   343 SDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMA 407
            ..||::.:..||..:||||..:||||:|||||.:|:::.|.|:||||.|:|||:|:|.....|..
  Fly   336 PSNVFISKWFPQPDILAHPKVKLFITHGGLLSTIESIHHGKPVLGLPFFYDQFLNVRRATQAGFG 400

  Fly   408 EVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMR 472
            ..||...||.:.|..||..||:.||:|..|::||:.:||:||||||||:|||||.||:|.|.|||
  Fly   401 LGLDHTTMTQQELKETIEILLKEPRFAQIARQMSERYRDQPMSPLDTAIWWTEYVLRHKGAYHMR 465

  Fly   473 LNTEDVPL--YYEWD-WGLLLG---LRFGIVFGSVIYLVYKLFQKTSARRR 517
            :..:|:..  |:..| .|:|||   |...|:.|    ::.||....:|:::
  Fly   466 VAGQDLGFFAYHSLDVIGVLLGGALLLVAIIVG----VLGKLTDFGNAKKK 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	157/447 (35%)
Ugt35B1	NP_524313.2	egt	8..466	CDD:223071	161/454 (35%)
Ugt35B1	NP_524313.2	MGT	26..438	CDD:273616	133/416 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445583
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D55476at33392
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800