DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and ugt1ab

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_998587.2	Gene:	ugt1ab / 406731	ZFINID:	ZDB-GENE-040426-2762	Length:	536	Species:	Danio rerio

Alignment Length:	550	Identity:	149/550 - (27%)
Similarity:	263/550 - (47%)	Gaps:	76/550 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAVLFCLFLQKDLYQDSVQAANIL-----GIFSYHFSSHNLVVRPLAKALVKRGHNVTLITP--- 64
            |....|||     ..:||||..:|     |       ||.|.::.|.:.:..|||.:.::.|
Zfish    22 LFAFLCLF-----SSESVQAGKVLVMPVDG-------SHWLSMKILVEEMSSRGHEMVVLVPETS 74

  Fly    65 --VGMPTDIEGVRHIRVP----KLNQRVQEM----IE-GDQILDFFGSKWIASLM-VVSMLYNMS 117
              :|...:.. .:..|||    :||..|..:    || ..:.:|..|:  :.:|: ..:|.....
Zfish    75 ILIGKSGNFT-TKSFRVPYSFDELNAHVDHIRKTAIEKAPRFIDIVGA--LGNLIQFTNMQVKAC 136

  Fly   118 SDILSDKGVQKMLQNRNERFDLVMLEPSALEALYGVVEHYNATLMGFSGGNVNWSTEEVAGNF-A 181
            ..:|.|:.:.|.|  |:.:||.::.:| .|.....:.::::...:.|..| :....:|.|... :
Zfish   137 EGLLYDEPLMKSL--RDMKFDALLTDP-FLPCGSVIADYFSIPAVYFLRG-IPCRLDEAAAQCPS 197

  Fly   182 PSINDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQ---LRIFKKFFNFSEQKFYNMR 243
            |....|....||:...:...::.|......||.|.|.:|....   .|..||..:::|...:.
Zfish   198 PPSFIPRFFTGYTDKMTFPQRMINTFMTVFEKYLCHQLFASFDELATRYLKKDTSYAELLGHG-- 260

  Fly   244 EKYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMD-DAEHGVIYFSMGQEIM 307
               :|.|:....|....:..:||::::||::..:.| |...:|::|:: ..|||.:.|::|.  |
Zfish   261 ---AVWLLRYDFSFEYPKPQMPNMVQIGGINCAKRA-PLTKELEEFVNGSGEHGFVVFTLGS--M 319

  Fly   308 VQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMP---NKSDNVYVIEQPPQRAVLAHPNTRLFITN 369
            |..|||...:...::..|..|||:|:   |..|   |...||.:::..||..:|.||..|.|:|:
Zfish   320 VSQLPEAKAREFFEAFRQIPQRVLWR---YTGPVPENAPKNVKLMKWLPQNDLLGHPKVRAFVTH 381

  Fly   370 GGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYA 434
            ||...:.|.:.:|||::.||:|.||..|.:.:..||:||.|...::|.|.|...::|::.:..|.
Zfish   382 GGSHGIYEGICNGVPMVMLPLFGDQGDNAQRLVSRGVAESLTIYDVTSEKLLVALKKVINDKSYK 446

  Fly   435 LKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLNTEDVPLYYEWDW---------GLLL 490
            .|..|:|...||||:.|||.||:|||:.:|:|.|.|:|      |..::.:|         |.||
Zfish   447 EKMMKLSAIHRDRPIEPLDLAVFWTEFVMRHKGAEHLR------PAAHDLNWIQYHSLDVIGFLL 505

  Fly   491 GLRFGIVFGSV---IYLVYKLFQKTSARRR 517
            .:...::|.:|   ::...|.|:|:..:::
Zfish   506 LILLTVIFVTVKSCMFCFRKCFKKSQKKKK 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	135/485 (28%)
ugt1ab	NP_998587.2	UDPGT	37..524	CDD:278624	138/517 (27%)
ugt1ab	NP_998587.2	egt	<279..513	CDD:223071	83/245 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.760