DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B3 and Ugt316A1

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001287111.1	Gene:	Ugt316A1 / 40079	FlyBaseID:	FBgn0036842	Length:	636	Species:	Drosophila melanogaster

Alignment Length:	564	Identity:	145/564 - (25%)
Similarity:	261/564 - (46%)	Gaps:	68/564 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 WLAVLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKR--GHNVTLITP----V 65
            :|..|.|         ..|..||:|.:|...:.||.|..|.|.:.||:.  .|:||||:|    .
  Fly     7 FLGTLLC---------GIVLGANVLTVFPSVWKSHYLFGRRLLQELVESSGNHSVTLISPHAAQE 62

  Fly    66 GMPTDIEGVRHIRVPKLNQRVQEM--------IEGDQILDFFGSKWIASLMVVSMLYNMSSDILS 122
            |:..:|..:|.:|:..|.:...:|        :....:::.|.....|....|.:|       ||
  Fly    63 GVDAEIPKIRELRIEGLRENWLDMGMSFEAEEMRAQSVMERFTRLIYAGTTNVDIL-------LS 120

  Fly   123 DKGVQKMLQNRNERFDLVMLEPSALEALYGVVEHYNATLMGFSGGNVNWSTEEVAGNFAPSINDP 187
            |..|:|:|.: .|:|||::::....:||.|:..:|....:..|....|.....:.||...|..||
  Fly   121 DPQVRKLLTS-GEKFDLLIVDLFLSDALLGLAFYYGIPTVAVSPTGANSWLNNMFGNPQSSSLDP 184

  Fly   188 ISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRIFKKFFNF--SEQKFY-NMREKYSVI 249
            .:.|.::...:...:|.|.:..|.|:|..:.....||..::...|..  .|...| ::.:..|:.
  Fly   185 SNFLPFTERMNTRQRILNSLMSTFERLTYNFFHLISQQSVYTNHFELLVKELPLYRDLTKNLSLA 249

  Fly   250 LVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQK----FMDDAEHGVIYFSMGQEIMVQF 310
            |:|:|..:...|:.:||::|||||||:...   |..|.|    ||:.|..||||||:|.::....
  Fly   250 LINSHPGLHYPRAYLPNMVEVGGLHLSHLN---DDNLPKHLLSFMESAPSGVIYFSLGADVETAQ 311

  Fly   311 LPEDMQQNLMKSLD------QFKQRVVWKTELYN----MPNKSDNVYVIEQPPQRAVLAHPNTRL 365
            ||   |:.|...||      :|...:.|:.|.:.    :|   :||.:.:..||:|:|.||..::
  Fly   312 LP---QEKLAIILDVFGHLKEFHFLLKWEKEEFTAEQVLP---ENVMIADWWPQQAILHHPQVKM 370

  Fly   366 FITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLEN 430
            ||::.|.|||.|::....|:|.:|:..:|.:..:.:...|::..:..:.:..:.|...||:|..|
  Fly   371 FISSCGQLSVWESISGQKPVLAIPILAEQEVMAKRLQRHGVSVTVGYDSLAYDSLLHGIRQLTLN 435

  Fly   431 PRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLNTEDVPLYYEWDWGLLLGLR-- 493
            ..|..|..::.:....|..:|:..||...:..|.:..|..::.:...:..:......:||.:.
  Fly   436 TSYVEKLGQLKERLISRDSTPVGKAVRKIQLILESGGADFLKSHANTLNFWRAEGVDVLLIIAVG 500

  Fly   494 -FGIV---FGSVIYLVYKLFQKTSARRRP-----FQVTGTVSQH 528
             |||:   |.::.:::.|.:...:|:.:|     .:|.|.|..:
  Fly   501 FFGILTIPFLAICFILRKSYHSQAAQDQPPYRTNLKVVGRVHSY 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	132/489 (27%)
Ugt316A1	NP_001287111.1	egt	1..480	CDD:223071	133/498 (27%)
Ugt316A1	NP_001287111.1	MGT	39..448	CDD:273616	115/425 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445635
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.850