DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B3 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_964007.2	Gene:	Ugt1a1 / 394436	MGIID:	98898	Length:	535	Species:	Mus musculus

Alignment Length:	515	Identity:	125/515 - (24%)
Similarity:	232/515 - (45%)	Gaps:	38/515 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVGMPTDIEG- 73
            :|.|:|      ..|...|..|.:|... .||.|.:..:.:.|.::||.|.:|.|.......||
Mouse    17 LLLCVF------GPSASHAGRLLVFPMD-GSHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKEGS 74

  Fly    74 ---VRHIRVPKLNQRVQEMIEGDQILDFFGSKWIASLMVVSMLYNMSSDILSDKGVQKMLQNRNE 135
               :|...||...:.|...:.......|....::..::.:.|.....|.:|. .|...:|.|..
Mouse    75 FYTLRKFPVPFQKENVTATLVELGRTAFNQDSFLLRVVKIYMKVKRDSSMLL-AGCSHLLHNAE- 137

  Fly   136 RFDLVMLEPSALEALY--------GVVEHYNATLMGFSGGNVNWSTEEVAGNFAPSINDPISSLG 192
              .:..||.|..:||.        .:|..|......:....:..|.:..|......::....||.
Mouse   138 --FMASLEESHFDALLTDPFLPCGSIVAQYLTVPTVYFLNKLPCSLDSEATQCPVPLSYVPKSLS 200

  Fly   193 YSRSN-SLLSKIYNWVHITEEKLLKHLIFRP---SQLRIFKKFFNFSEQKFYNMREKYSVILVNN 253
            ::... :.|.::.|.:....|..:..:::.|   ....|.:|     |....::....|:.|:.:
Mouse   201 FNSDRMNFLQRVKNVLLAVSENFMCRVVYSPYGSLATEILQK-----EVTVQDLLSPASIWLMRS 260

  Fly   254 HISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMD-DAEHGVIYFSMGQEIMVQFLPEDMQQ 317
            .......|..:||::.:||::..: .:|...:.:.::: ..|||::.||:|.  ||..:||....
Mouse   261 DFVKDYPRPIMPNMVFIGGINCLQ-KKPLSQEFEAYVNASGEHGIVVFSLGS--MVSEIPEKKAM 322

  Fly   318 NLMKSLDQFKQRVVWKTELYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSG 382
            .:.::|.:..|.|:|:.......|.:.|..:::..||..:|.||.||.|||:.|...:.|.:.:|
Mouse   323 EIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNG 387

  Fly   383 VPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDR 447
            ||::.:|:|.||..|.:.:..||....|:..|||.:.|.:.::.::.|..|.....::|...:||
Mouse   388 VPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDR 452

  Fly   448 PMSPLDTAVWWTEYALRNKDASHMRLNTEDVPLYYEWDWGLLLGLRFGIVFGSVIYLVYK 507
            |:.|||.||:|.||.:|:|.|.|:|....|: .:|::....::|....||. :|:::|:|
Mouse   453 PIEPLDLAVFWVEYVMRHKGAPHLRPAAHDL-TWYQYHSLDVIGFLLAIVL-TVVFIVFK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	113/472 (24%)
Ugt1a1	NP_964007.2	egt	20..507	CDD:223071	122/507 (24%)
Ugt1a1	NP_964007.2	UDPGT	30..526	CDD:278624	120/496 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840311
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.640