DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B3 and Ugt1a9

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_964006.2	Gene:	Ugt1a9 / 394434	MGIID:	3576092	Length:	528	Species:	Mus musculus

Alignment Length:	522	Identity:	126/522 - (24%)
Similarity:	246/522 - (47%)	Gaps:	58/522 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 CLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITP-----VGMPTDIE 72
            ||.|...|    .||..:|.:  ....||...::.:.:.|:.|||.|.::.|     :|...:..
Mouse    13 CLLLASGL----AQAGRLLVV--PMDGSHWFTMQMVVEKLIHRGHEVVVVIPEVSWQLGKSLNCT 71

  Fly    73 GVRHIRVPKLNQRVQEMIEGDQILDFFGSKW------IASLMVVS------MLYNMSSDILSDKG 125
                ::...::..::::....:.|.:  ::|      |.|.:..|      :.::....:.:||.
Mouse    72 ----VKTYSISHTLEDLDREFKYLSY--TQWKTPEHSIRSFLTGSARGFFELTFSHCRSLFNDKK 130

  Fly   126 VQKMLQNRNERFDLVMLEPSALEALYGVVEHYNATLMGFSGGNVNWSTEEVAGNFAPSINDPISS 190
            :.:.|:.|  .||.|.|:|..:..|. |.::::...:.|:.|......||  |...||:...:..
Mouse   131 LVEYLKQR--FFDAVFLDPFDVCGLI-VAKYFSLPSVIFARGVFCDYLEE--GAQCPSLPSYVPR 190

  Fly   191 LGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQ------LRIFKKFFNFSEQKFYNMREKYSVI 249
            |....::::..|         |::..|||:....      ||...:..:...|....|.:.:|.:
Mouse   191 LFSKYTDTMTFK---------ERVWNHLIYIEEHAFCSYFLRTAVEVASEILQTPVTMTDLFSPV 246

  Fly   250 ---LVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMD-DAEHGVIYFSMGQEIMVQF 310
               |:.....:...|..:||::.:||::..: .:....:.:.::: ..|||::.||:|.  ||..
Mouse   247 SIWLLRTDFVLEFPRPVMPNMVFIGGINCLQ-KKSLSKEFEAYVNASGEHGIVVFSLGS--MVSE 308

  Fly   311 LPEDMQQNLMKSLDQFKQRVVWKTELYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSV 375
            :||.....:.::|.:..|.|:|:.......|.:.|..:::..||..:|.||.||.|||:.|...:
Mouse   309 IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGI 373

  Fly   376 MEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKM 440
            .|.:.:|||::.:|:|.||..|.:.:..||....|:..|||.:.|.:.::.::.|..|.....::
Mouse   374 YEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRL 438

  Fly   441 SQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLNTEDVPLYYEWDWGLLLGLRFGIVFGSVIYLV 505
            |...:|||:.|||.||:|.||.:|:|.|.|:|....|: .:|::....::|....||. :|:::|
Mouse   439 SSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDL-TWYQYHSLDVIGFLLAIVL-TVVFIV 501

  Fly   506 YK 507
            :|
Mouse   502 FK 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	114/479 (24%)
Ugt1a9	NP_964006.2	egt	9..500	CDD:223071	124/517 (24%)
Ugt1a9	NP_964006.2	UDPGT	24..519	CDD:278624	120/507 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840349
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.640