DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	526	Identity:	130/526 - (24%)
Similarity:	248/526 - (47%)	Gaps:	56/526 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LAVLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITP-----VGM 67
            |.:..||||....    .||..:|.:  ....||...::.:.:.|..|||.|.::.|     :|.
  Rat    10 LPLCVCLFLASGF----AQAGRLLVV--PMDGSHWFTMQMIVEKLSHRGHEVVVVIPEVSWHMGK 68

  Fly    68 PTDIEGVRHIRVPKLNQRVQEMIEGDQILDFFG-SKW------IASLMVVS------MLYNMSSD 119
            ..:..    ::...::..::::   :....||. ::|      :.||:..|      :|::....
  Rat    69 SLNFT----VKTYSVSYTLEDL---NYHFKFFAHNQWKTQEVGMFSLLKHSGKGFFELLFSHCRS 126

  Fly   120 ILSDKGVQKMLQNRNERFDLVMLEPSALEALYGVVEHYNATLMGFSGGNVNWSTEEVAGNFAPSI 184
            :..||.:.:.|  :...||.|.|:|..:..|. :.::::...:.||||......:|  |...||.
  Rat   127 LFKDKKLVEYL--KQSSFDAVFLDPFDVCGLI-LAKYFSLPSVVFSGGIFCHYLDE--GAQCPSP 186

  Fly   185 NDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRIFKKFFNFSEQKFYNMREKYSVI 249
            ...:..:....::::..|...|.|::   .:|...|.|...:...:..:...|....||:.:|.:
  Rat   187 PSYVPRILSKFTDTMTFKERVWNHLS---YMKERAFCPYFFKTAVEIASEVLQTPVTMRDLFSPV 248

  Fly   250 LVNNHISMGRV-------RSNVPNIIEVGGLHLTEPAEPCDSKLQKFMD-DAEHGVIYFSMGQEI 306
                .|.|.|.       |..:||::.:||::..: .:|...:.:.::: ..|||::.||:|.
  Rat   249 ----SIWMFRTDFVLEFPRPVMPNMVYIGGINCHQ-GKPLSKEFEAYVNASGEHGIVVFSLGS-- 306

  Fly   307 MVQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGG 371
            ||..:||.....:.::|.:..|.|:|:.......|.:.|..:::..||..:|.||..|.|||:.|
  Rat   307 MVSEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSG 371

  Fly   372 LLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALK 436
            ...:.|.:.:|||::.:|:|.||..|.:.:..||....|:..|||.:.|.:.::.::.|..|...
  Rat   372 SHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKEN 436

  Fly   437 AKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLNTEDVPLYYEWDWGLLLGLRFGIVFGSV 501
            ..::|...:|||:.|||.||:|.||.:|:|.|.|:|....|: .:|::....::|....||. :|
  Rat   437 IMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDL-TWYQYHSLDVIGFLLAIVL-TV 499

  Fly   502 IYLVYK 507
            :::|||
  Rat   500 VFIVYK 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	117/483 (24%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	123/506 (24%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	73/245 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810