DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B3 and ugt-8

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_504315.1	Gene:	ugt-8 / 186768	WormBaseID:	WBGene00019234	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	132/560 - (23%)
Similarity:	228/560 - (40%)	Gaps:	95/560 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHLEFYWLAVLFCLFLQKDLYQDSVQAANILGIFSYHFS-SHNLVVRPLAKALVKRGHNVTLITP 64
            ||:: ..|::|..|        .||...||| ||:..|. ||...:..:|..:...||||||..|
Worm     1 MHVK-NLLSILLVL--------GSVSCKNIL-IFNPIFGLSHVKFISKMANIIADHGHNVTLFQP 55

  Fly    65 VGMP-TDIEGV---RHIRVPKLN---QRVQEMIEGDQILDFFGSKWIASLM-------------V 109
            ..:. .:.||:   ::|.:  :|   ....|:::.:...  |.:.|.:.||             :
Worm    56 FHIALKNTEGLIKNKYIEI--INYYPDHYDELLKTETAT--FPAFWDSHLMNNPVLSAFMIPKAI 116

  Fly   110 VSMLYNMSSDILSDKGVQKMLQNRNERFDLVMLEPSALEALYGVVEHYNATLMGFSGGNVNWSTE 174
            .......::.:|.||.....|::||  ||:::.|...|..:| :....|...:..      ||.
Worm   117 AGEFERTATQLLKDKVALDDLKSRN--FDVIISETFELTGMY-IAHMLNVPCIPV------WSA- 171

  Fly   175 EVAGNFAPSINDPISSLGYSRSN-----------SLLSKIYNWVHIT---------EEKLLKHLI 219
             |......:|....||||||:..           ..|:.:|.....|         :...::..:
Worm   172 -VRFTIFNNIFGQPSSLGYSQQPFSKLAPEAGFIDRLNDVYRNFFFTITMDGMGQYQNDFIEKAV 235

  Fly   220 FRPSQLRIFKKFFNFSEQKFYNMREKYSVILVNNHISMGRVRSNVPNIIEVGG----LHLTEPAE 280
            .||  |..:|.....:...|.|..|.....:           .....|:.:||    |...:..:
Worm   236 GRP--LPYWKDLIKEAPVYFTNSNEYLDFAV-----------PTTATIVHIGGFTMDLEKMKHVD 287

  Fly   281 PCDSKLQKFMDDAEHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQ-RVVWKTELYNMPNKS- 343
            |...|..|.:::.|..|: .|.|..|....:|::.:..::|..:.... ..:||.|..::..:.
Worm   288 PLPDKYAKILEERESTVL-ISFGSVIRSYQMPDNFKAGIIKMFESLPDVTFIWKYERDDVEFQKK 351

  Fly   344 --DNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGM 406
              .||::.:..||.::||....:||:|:|||.|.||..|:|.|.|.:|:|.||..|...:...|.
Worm   352 LPKNVHLKKWVPQHSLLADNRVKLFVTHGGLGSTMEVAYTGKPALMVPIFGDQPENANMLARHGG 416

  Fly   407 AEVLDANEMT-LEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALR--NKDA 468
            |...|..|:. .|.|..|||.::.||:|...|:::.:....:|:.|....:...|:|:.  |..:
Worm   417 AISYDKFELADGEKLAITIRDMVRNPKYNKNAQELLKVLSHQPIDPKLNLMKHLEFAMEFPNLRS 481

  Fly   469 SHMRLNTEDVPLYYEWDWGLLLGLRFGIVFGSVIYLVYKL 508
            ....:|...:..:|..|....|.|    :|...:||.:|:
Worm   482 QVPAINQMGLIAHYYLDVIFFLSL----IFILTVYLTFKI 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	120/510 (24%)
ugt-8	NP_504315.1	UDPGT	30..516	CDD:278624	118/518 (23%)
ugt-8	NP_504315.1	egt	<284..462	CDD:223071	51/178 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810