DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and ugt-61

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_504274.2	Gene:	ugt-61 / 185500	WormBaseID:	WBGene00018206	Length:	530	Species:	Caenorhabditis elegans

Alignment Length:	526	Identity:	113/526 - (21%)
Similarity:	237/526 - (45%)	Gaps:	96/526 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LAKALVKRGHNVTLIT---PVGMPTDIEGVRHIRVPKLNQRVQ----EMIEGDQILDFFGSKWIA 105
            :|:.|...||:||::.   ..|..::::..:.::..:|:..|:    :.||.:|....:.:..:.
Worm    37 VAEVLAIGGHDVTMLMVNHMAGFESNVKVPKGVKTYQLDAAVEGITKQSIEKEQSAMLYKNMGLK 101

  Fly   106 SLMVVSMLYNMSSDILSDKGVQKMLQNR-------NERFDLVMLEPSALEALY-----GVVEHYN 158
            .:..:..:::....:|.| |.:.:|:|:       :|:||:      |...:|     |::.|
Worm   102 DMPQMMAMFSRMGKLLQD-GCRIILRNKEFLKWLEDEKFDV------AYTHIYSTCPLGLIHH-- 157

  Fly   159 ATLMGF----SGGNVNWSTEEVAGNFAPSINDPI-----SSLGY-SRSNSLLSKIYNWVHITEEK 213
            |.:..:    ||..:::.::.|.....||...|:     ..:|: .|:.|.:..:.       ..
Worm   158 AKIPSWVWLNSGPLMDYVSQAVGVPILPSYVPPVLMASHDEMGFVQRTKSFIGHVL-------MS 215

  Fly   214 LLKHLIFRPSQLRIFKKFFNFSEQKF---YNMREKYSVILVNNHISMGRVRSNVPNIIEVGGLHL 275
            ::...|....:..||:|..|  :..|   .::..|..:::||::......|..:..:|.:|||.:
Worm   216 VMHRRISSDEETAIFRKELN--DPSFPHTMDIGAKCPLVIVNSNELYDLPRPTLAKVINIGGLGV 278

  Fly   276 -TEPAEPCDSKLQKFMDDAEHGVIYFSMGQEIMVQFLPEDMQQNLMKSL--------------DQ 325
             .:.|:|...:.:| :.:..:|:|.||.|.......:|...:.:|:::.              |.
Worm   279 GFDSAKPLTGEFKK-ISETGNGLIVFSFGSVAAAHEMPLAWKNSLLEAFASLPDYQFVMRYEGDD 342

  Fly   326 FKQRVVWKTELYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPV 390
            .|.|:            .:||::.:..||:.:|.|..|:.|||:||..|:.||:.:|||::.:.:
Worm   343 LKDRL------------PENVHLSKWLPQKDLLLHEKTKAFITHGGYNSLQEAISAGVPLITIAL 395

  Fly   391 FFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTA 455
            ..||..|.:.....|.|..::...::.|.:...:|::|||..|..|..::|...|.:||.|.:..
Worm   396 MGDQPKNSQIAKKHGFAVNIEKGTISKETVVEALREILENDSYKQKVTRLSAMVRAQPMKPAERL 460

  Fly   456 VWWTEY-----ALRNKDASHMRLNTEDVPLYYEWDWGLLLGLRFGIVFGSVI----YLVYK-LFQ 510
            :.|:|:     .|.|...:..:||      :|::....::|..|.:|.  |:    :|:.| :|:
Worm   461 LKWSEFLAEFKTLDNLVPAGQKLN------FYQYHSLDVIGFLFLVVL--VVFYIGFLILKAVFR 517

  Fly   511 KTSARR 516
            |...||
Worm   518 KCCRRR 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	99/469 (21%)
ugt-61	NP_504274.2	UDPGT	37..519	CDD:278624	110/520 (21%)
ugt-61	NP_504274.2	egt	<251..471	CDD:223071	57/232 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14157
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810