DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and ugt-37

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_504811.2	Gene:	ugt-37 / 184293	WormBaseID:	WBGene00017332	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	543	Identity:	126/543 - (23%)
Similarity:	235/543 - (43%)	Gaps:	116/543 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 FSYHF--------SSHNLVVRPLAKALVKRGHNVTLITP--VGMPTDIEGVRHIRVPKLNQRVQE 88
            |||:|        .||......:|..|.:.|||||..||  :...:.|..|:|.: ..::....|
Worm    15 FSYNFLIFSPLFGHSHTTFFAKIADTLSEAGHNVTFFTPTIIRKFSKINYVKHTK-HVIHLEPSE 78

  Fly    89 MIE--GDQILDFFGSK-W-----IASLMVVSMLYN-----------MSSDILSDKGVQKMLQNRN 134
            .:|  |:|:.|...|: |     :|.:..:..|:|           .:.|:|.:  :::|
Worm    79 KLERYGNQMEDVDISRFWTDDSSMAEMFPMIKLFNEMFAEQAFVLGQNLDVLDE--LKEM----- 136

  Fly   135 ERFDLVMLEPSALEALYGVVEHYNATLMGFSGGNVNWSTEEVAGNFAPS---INDP--ISSLGYS 194
             :||:::.|..| |..|.::|:....                  .|.||   :.||  :.|:|..
Worm   137 -KFDVMIFERFA-ECAYPLLEYLEIE------------------TFIPSSSLLFDPNLLISIGEP 181

  Fly   195 RSNSL----LSKIYNWVHITEEKL------LKHLIFRPSQLRIFKKFFNFSE-QKFYNMREKYSV 248
            |..|.    :||..:.:.:||..|      :.|.:....:.:.|:..:...: ||   |....|.
Worm   182 RIPSTVPLPMSKFTDKMTMTERLLNAIAVPIFHSLLPTHEFKSFRPPYQAIDIQK---MEHLSSF 243

  Fly   249 ILVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMD------DAEHGVIYFSMGQEIM 307
            ||.|::..:...|..:...:::||:.:    :..:.|:.|..:      |.....|..|.|..::
Worm   244 ILSNSNPYIDYPRPTLEKNVQIGGISV----DVENLKIHKVNEEWDRILDMRQKTILVSFGSVML 304

  Fly   308 VQFLPEDMQQNLMKSLDQFKQ-RVVWK-----TELYNMPNKSDNVYVIEQPPQRAVLAHPNTRLF 366
            .:.:|.:.::.|.|::.||.: ..:||     |:|:  .::::|::.....||.|:||......|
Worm   305 SKDMPVENKKILAKTMKQFPEVTFIWKYEFNDTDLF--ASETENIHFSSWVPQTALLADRRLTAF 367

  Fly   367 ITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNL----RGMAEVLDANEMTLEILTSTIRKL 427
            .|:.||.||.|..|.|.|.:..|:|.||   :||..:    .|..|:...:....|.:..|:|.:
Worm   368 FTHAGLGSVNEVSYLGKPSIMCPIFADQ---MRNAKMLARHNGSIEISKYDLGNGEKIEKTLRTI 429

  Fly   428 LENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYA-----LRNKDASHMRLNTEDVPLYYEWDWG 487
            |.:..|.|.|:|::....::|:.|.:..:...|:|     |.:.|....:|:      :.|:
Worm   430 LFDDSYRLSAEKLAHQLANQPVKPKELLLRHAEFAAQFGRLPSLDPYSRQLS------FVEY--- 485

  Fly   488 LLLGLRFGIVFGSVIYLVYKLFQ 510
            .|:.:...::|.|:: :|..|||
Worm   486 FLIDVAAILIFSSLL-IVVVLFQ 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	116/497 (23%)
ugt-37	NP_504811.2	Glycosyltransferase_GTB_type	1..504	CDD:299143	123/538 (23%)
ugt-37	NP_504811.2	UDPGT	37..510	CDD:278624	120/521 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810