DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and ugt-17

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001122841.1	Gene:	ugt-17 / 179406	WormBaseID:	WBGene00007422	Length:	540	Species:	Caenorhabditis elegans

Alignment Length:	568	Identity:	123/568 - (21%)
Similarity:	252/568 - (44%)	Gaps:	102/568 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHLEFYWLAVLFCLFLQKDLYQDSVQAANILGIFSYHF-SSHNLVVRPLAKALVKRGHNVTLITP 64
            |:.::|.:.:||.:....:.|:       :| :|:..| :||:..:..::..|:..||:||::.|
Worm     1 MNFQYYIIFILFSIIDYSNSYK-------VL-VFNPAFGASHSNFLGKISDILIDAGHDVTMLIP 57

  Fly    65 VGMPTDIEGVRHIRVPKLNQRVQEMIEGDQ---ILDFF---GSKWIASLMV------VSMLYNMS 117
            :.|    :|.:|:...|   :|:.:|..||   .::.:   |::.:....:      :::.:.|:
Worm    58 IAM----QGKKHLVGSK---KVKNIIRIDQDPRSIELYKQTGAEDVLRKKIWKVESDIALFFKMA 115

  Fly   118 SDILSDKGVQ--------KMLQN-RNERFDLVMLEPSALEALYGVVEH------YNATLMGFSG- 166
            .:.....|.|        ::|:. :||.|:|.:.| |.....|.:.:|      .||..:.|..
Worm   116 GNFSKTCGYQCQHVFQQTEILEKLKNEHFELGITE-SLFICGYPLFDHLGVKTIINADSVLFMDI 179

  Fly   167 -----GNVNWSTEEVAGNFAPSINDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLR 226
                 |..:.||      |.|::..|::.     ..:|:.:|.|.:.:........:.|. .:|.
Worm   180 VKCTLGEPSSST------FYPALISPMTD-----KMTLVERIKNAIQMLIPVYFSKMRFE-EELS 232

  Fly   227 IFKKFFNFSEQKFYNMREKYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMD 291
            :.:.::|.| :.:..:.|..:..:||::..:......:|..:.:||:.: :..:....||.|..|
Worm   233 MIEPYYNGS-KTWEELLENVAFNMVNSNRYLDYASPTLPKTVFIGGMQV-KTKKQGTPKLNKEWD 295

  Fly   292 D-----AEHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQ----RVVWKTELYNMPNKS---- 343
            |     .|:  :..|.|.......:|::.:::.   ||.|..    ..:||   |...|.:
Worm   296 DLLNIRKEN--VLVSFGSNAFSSEMPDEFKKSF---LDVFASMPEITFIWK---YEQENSTIAMH 352

  Fly   344 -DNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVP----ILGLPVFFDQFINLRNVNL 403
             .||.:....||..:||.....||:|:|||.|.:|..|.|.|    |..:|:..||..|...:..
Worm   353 LSNVKMTTWMPQSDLLADNRLSLFVTHGGLGSSIELAYQGTPAVVNIFKIPLMADQPRNAHMLTR 417

  Fly   404 RGMAEVLDANEM-TLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALR--- 464
            .|.|..||...: ..:::...|:.:|:|..|...|:|::|...|:|.:|.:..:...::|::
Worm   418 HGGAIQLDKTNLDNPQMIRDAIKTILDNDSYTENARKLAQILEDQPYTPAEVVLKHCDFAVKFGV 482

  Fly   465 --NKDASHMRLNTEDVPLYYEWDWGLLLGLRFGIVFGSVIYLVYKLFQ 510
              ...:...:||   |..:|.:|  :|:.:.| ::...|:::|..:||
Worm   483 LDTLQSEGRKLN---VFQFYSYD--ILVVVCF-LIITVVVFIVLYVFQ 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	110/516 (21%)
ugt-17	NP_001122841.1	egt	1..513	CDD:223071	119/555 (21%)
ugt-17	NP_001122841.1	UDPGT	22..538	CDD:278624	118/547 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860