DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and ugt-24

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_500931.3	Gene:	ugt-24 / 177380	WormBaseID:	WBGene00016762	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	125/553 - (22%)
Similarity:	224/553 - (40%)	Gaps:	120/553 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 ANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPV--GMPTDIEGVRH---IRVPKLNQRVQ 87
            :|:.|      .||..|:..:|..|...|||||:..|:  ....|...|:.   |.:....:.|:
Worm    26 SNLYG------HSHIKVLNTVADTLTDAGHNVTIFRPIIESSQLDKSSVKTKNVIYIEPDEEVVE 84

  Fly    88 EMIEGDQILDFFGSKWIASLMVVSMLYNMSSDILSDKGV--------QKML-QNRNERFDLVMLE 143
            :|.:.||   |.||.|.......|.:...|:.::...|.        ||:| |.|:|.|||.:.|
Worm    85 KMSKIDQ---FSGSLWTFDSTHPSAMIAKSNALVGFFGTQCKKVMRQQKILDQLRDENFDLAITE 146

  Fly   144 PSALEALYGVVEH----------------YNATLMGFSGGNVNWSTEEVAGNFAPS----INDPI 188
            | .....|.:.|:                :.:.::|          :.:|.::.|.    .||.:
Worm   147 P-VDGCAYAIFEYLKIRDHVTVLSCVRFDHVSDILG----------QPIAPSYVPGTQSFFNDRM 200

  Fly   189 SSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRIFKKFFNFSEQKFYNMREKYSV----- 248
            :                    .:|:||..:.|...:.    .|.|..:|::...::...:
Worm   201 T--------------------MKERLLNFIQFYYGRF----TFANILDQEYEMAKDILGIQRSWR 241

  Fly   249 -------ILVNNHISMGRVRS-NVPNIIEVGG--LHLTEPAEPCDSKLQKFMDDAEHGVIYFSMG 303
                   .:.:|||.:....| ....||.:||  :...|.:...|.|....::..:..|: .|.|
Worm   242 EVLPEASFIFSNHIPVLDFPSPTFDKIIPIGGFTVKTNEKSLKIDKKWDAILNIRKKNVL-ISFG 305

  Fly   304 QEIMVQFLPEDMQQNLMKSLDQFKQRV-VWKTELYNMPNKS-----DNVYVIEQPPQRAVLAHPN 362
            .....:.:||:.::.|::......... :||   |..||.:     |||::....||..:||...
Worm   306 SNAKSKDMPEEYKKTLLRVFSSMPDTTFIWK---YEDPNVNIAKNLDNVFISSWLPQNELLADSR 367

  Fly   363 TRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMT-LEILTSTIRK 426
            ..:|:|:|||.||||....|.|.:.:|:|.||..|.:.:...|.|.||...::: .:::..|:..
Worm   368 VTVFVTHGGLASVMELALMGKPAIMIPIFADQGRNAQMLKRHGGAAVLQKTDLSNFDLVRDTLND 432

  Fly   427 LLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALR-------NKDASHMRLNTEDVPLYYEW 484
            :|..|.|.|.|||:::...::|.:..:..|...|:|.|       :....|     :::..||..
Worm   433 VLTKPSYKLNAKKLAEMLNNQPTNAKEVLVKHVEFAARFGKLPMLDNYGRH-----QNIVEYYFI 492

  Fly   485 DWGLLLGLRFGIVFGSVIYLVYKLFQKTSARRR 517
            |   :|.:...::. ||.|:..:|.:...:|.|
Worm   493 D---ILTIILSVLI-SVFYIFVRLLRFMLSRNR 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	114/500 (23%)
ugt-24	NP_500931.3	UDPGT	32..519	CDD:278624	121/537 (23%)
ugt-24	NP_500931.3	egt	<251..504	CDD:223071	67/265 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860