DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and ugt-60

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001021158.1	Gene:	ugt-60 / 176366	WormBaseID:	WBGene00007402	Length:	507	Species:	Caenorhabditis elegans

Alignment Length:	545	Identity:	125/545 - (22%)
Similarity:	229/545 - (42%)	Gaps:	132/545 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVGM-------- 67
            :||:||      ..|.:..||.|.....:||.|....||:.|...||:|.:.|.:.|
Worm     5 IFCIFL------SVVDSLRILQIVPGFTNSHVLFNYRLAETLRFLGHDVKMWTQMEMAMLDTGNN 63

  Fly    68 --PTDIEGVRHIRVPKLNQRVQEMIEGDQILDFFGSKWIASLMVVSMLYNMSSDI---------L 121
              |   |||...|:|         |.....|...|.|...|:|..|   ..:.|:         :
Worm    64 KLP---EGVSEYRIP---------IHFTDTLKTEGLKVFQSMMFES---GDAHDLWWTGQEFKDM 113

  Fly   122 SDKGVQKMLQN--------RNERFDLVM-----LEPSALEALYGV-----VEHYNATLMGFSGGN 168
            ..:..::||::        |.:.||:.:     |.|.|:.....|     :.| ..::..||...
Worm   114 RVEACEQMLRHDESVYEDFRKDGFDVAIAHFHDLCPLAIAKKMNVKRVIWITH-GTSIYEFSAVQ 177

  Fly   169 VNWSTEEVAGNFAPS-INDPISSLGYSR------SNSL--LSKIYNWVHITEEKLLKHLIFRPSQ 224
            :...|       .|| |..|:||.|:|:      .|:|  || :.::|::.:..|:...:|
Worm   178 LGLRT-------IPSTIPHPLSSAGFSQLFLDRVQNTLWHLS-LLDFVNLPQNLLVDENLF---- 230

  Fly   225 LRIFKKFFNFSEQKFYNMREKYSVILVNNHISMGRVRSNVPNIIEVGG----------LHLTEPA 279
               :::|....:...:::                 .::.||:::..|.          :|:....
Worm   231 ---YREFVGADQDDLWDL-----------------AKTTVPSLLINGDRMLDFPRPLPIHIAFSG 275

  Fly   280 EPCDSK-----LQKFMDD----AEHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFK-QRVVWKT 334
            |...||     ::|:::|    ...|:|.||:|.......:|..|..:.:.:..:.| ..::|:.
Worm   276 ELGVSKGKKLVMEKWLEDIIEKPSDGLIVFSLGTVSNTTNMPAQMINSFLGAFGKLKTYTILWRM 340

  Fly   335 E-LYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINL 398
            | ......|.:|:::::..||:.::.||..:|.|.:||..|.:||..:|:|.:.:|:|.||.||.
Worm   341 EKSVAGAEKYENLHLVKWLPQKDIMRHPKMKLMIAHGGYNSFLEAAQAGIPAVLMPLFADQKINA 405

  Fly   399 RNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRD----RPMS------PLD 453
            :.....|||.|||..::|:..:...|::.|: |.|:..|||:|....|    :|.|      .|.
Worm   406 KRAQRYGMATVLDKLDLTINNVYGAIKEALK-PEYSTNAKKLSAMLSDQVARKPYSALRYSLKLA 469

  Fly   454 TAVWWTEYALRNKDASHMRLNTEDV 478
            |:...:.:.|:::..|.:..:..|:
Worm   470 TSPKPSLFTLKSQHLSFLEFHNLDI 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	123/531 (23%)
ugt-60	NP_001021158.1	Glycosyltransferase_GTB_type	17..>161	CDD:299143	37/158 (23%)
ugt-60	NP_001021158.1	egt	<253..464	CDD:223071	56/211 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158484
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.840