DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and ugt-28

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_491437.1	Gene:	ugt-28 / 172086	WormBaseID:	WBGene00015693	Length:	537	Species:	Caenorhabditis elegans

Alignment Length:	562	Identity:	130/562 - (23%)
Similarity:	247/562 - (43%)	Gaps:	82/562 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHLEFYWLAVLFCLFLQKDLYQDSVQAANILGIFSYHF-SSHNLVVRPLAKALVKRGHNVTLITP 64
            |.|:|...:..||          |..:.||| ::|..| :||:..:..||..|.:||||||.:.|
Worm     1 MLLKFLIFSSFFC----------STSSLNIL-VYSPAFAASHSNFLGKLADTLTERGHNVTYLMP 54

  Fly    65 VGMP---TDIEGVRHIRVPKLNQRVQEMIE-------GDQILDFFGSKWIASLMVVSMLYNMSSD 119
            |..|   .:..||:..:...:.:..:||:.       ..:|::.|   | .|.|..|...:|.|.
Worm    55 VVDPEKRDECIGVKLTKDLVIVEPDEEMMSFKKGSTPNGEIMELF---W-KSEMDSSNSRDMFSF 115

  Fly   120 ILSD-----------KGVQKMLQNRNERFDLVMLEPSALEAL-----YGVVEHYNATLMGFSGGN 168
            ..||           :.:.:.:::||  ||:.:|||..:..|     .|:.:...|:...|....
Worm   116 FNSDMKLACRNFHKRRDIFEQMKSRN--FDVAILEPVTICGLGFVKALGIEKTILASSSTFYDAV 178

  Fly   169 VNWSTEEVAGNFAPSINDPISSLGYSRSNSLLS---KIYNWVHITEEKLLKHLIFRPSQLRIFKK 230
            :::..|.:..::.||        |:|.:..:::   :..||:.:.|..:..|.:| ..:::.:::
Worm   179 MDYIGEPLDYSYVPS--------GFSVTGDVMTMAERYENWMVVKEINIALHDMF-DGEMKSYRE 234

  Fly   231 FFNFSEQKFYNMREKYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMDD--- 292
            |.......:..:....|:..||.:..:...|:.:...:.:||:.:...... :.||.|..:|
Worm   235 FLGEDLPNWRELLSSASIFFVNANPFLDFPRAVLQKTVPIGGISINLKWIK-EQKLTKDWEDILE 298

  Fly   293 AEHGVIYFSMGQEIMVQFLPEDMQQNLM---KSLDQFKQRVVWKTELYNMPNKSDNVYVIEQPPQ 354
            .....:..|.|..:...::|:..:..|:   ||:........::::..:..:...|::..:..||
Worm   299 KRTKTVLISFGSMVKSAYMPKIWRNGLLEVIKSMPDVTFIFKYESDEVSFADGISNIHFSKWVPQ 363

  Fly   355 RAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEM-TLE 418
            .|:|..|....|:|:|||.|.||..|||.|.:.:|||.||..|.|.:........|..|.| .::
Worm   364 TALLNDPRLSAFVTHGGLGSTMELAYSGKPGVVIPVFADQIRNARMIARHNGVIYLHKNSMENVK 428

  Fly   419 ILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYA-----LRNKDASHMRLNTEDV 478
            :....:..:|.:..|...|:|::....::|.||::..:.:||:.     ..|.|.....||
Worm   429 VTRKALTDVLYDESYKKNAEKLTDILMNQPYSPMENVIKYTEFVGEHGPFPNTDPYGRHLN---- 489

  Fly   479 PLYYE---WDWGLLLGLRFGIVFGSVIYLVYK-LFQKTSARR 516
              |::   :|...|..| |.|..|::|.:..: ::||  ||:
Worm   490 --YFQKTFFDIYALFAL-FYISVGTIIAISIRFIYQK--ARK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	111/500 (22%)
ugt-28	NP_491437.1	UDPGT	40..536	CDD:278624	115/512 (22%)
ugt-28	NP_491437.1	egt	<193..472	CDD:223071	62/288 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.860