Protein Alignment Ugt303B3 and UGT3A1

DIOPT Version :10

• Sequence 1: NP_651152.1
• Gene: Ugt303B3 / 42774
• FlyBaseID: FBgn0039085
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: XP_047272663.1
• Gene: UGT3A1 / 133688
• HGNCID: 26625
• Length: 526
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 130/566 - (22%)
• Similarity: 245/566 - (43%)
• Gaps: 129/566 - (22%)

  Fly     6 YWLAVLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVG---M 67
            |||:....: |:|.|.:.:.:...:.|       ||.|::..:::.|.:.|||||::...|   :
Human    11 YWLSGPTGI-LKKALQRPTTEKYWLCG-------SHYLLLDRVSQILQEHGHNVTMLHQSGKFLI 67

  Fly    68 PTDIEGVRHIRV-----PKLNQR---------VQEMIEGD-------QILDFFGSKWIASLMVVS 111
            |...|..:..:|     |:.:|:         ::..::|.       ::::.||::
Human    68 PDIKEEEKSYQVIRWFSPEDHQKRIKKHFDSYIETALDGRKESEALVKLMEIFGTQ--------- 123

  Fly   112 MLYNMSSDILSDKGVQKMLQNRNERFDLVMLEPSALEALYGVVEHYNATLMGFSGGNVNWSTEEV 176
                 .|.:||.|.:...|  :||.:|||.:|  |.:....::                  .|::
Human   124 -----CSYLLSRKDIMDSL--KNENYDLVFVE--AFDFCSFLI------------------AEKL 161

  Fly   177 AGNFAPSINDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRIFKKFFNFSEQKFYN 241
            ...|...:.....||.:...:.|     ::|.:....|..|:.|. .:::.|..||:||..: ::
Human   162 VKPFVAILPTTFGSLDFGLPSPL-----SYVPVFPSLLTDHMDFW-GRVKNFLMFFSFSRSQ-WD 219

  Fly   242 MRE-----------------------KYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCD 283
            |:.                       |..:..||:..:....|..:||.:.:||| :.:|.:|..
Human   220 MQSTFDNTIKEHFPEGSRPVLSHLLLKAELWFVNSDFAFDFARPLLPNTVYIGGL-MEKPIKPVP 283

  Fly   284 SKLQKFMDD-AEHGVIYFSMGQEIMVQFLPEDMQQNLMKSLD----QFKQRVVWKTELYNMP--- 340
            ..|..|:.: .:.|.:..:.|     ..|.....|.::|.:.    ...|.|:|..:..:.|
Human   284 QDLDNFIANFGDAGFVLVAFG-----SMLNTHQSQEVLKKMHNAFAHLPQGVIWTCQSSHWPRDV 343

  Fly   341 NKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRG 405
            :.:.||.:::..||..:||||:.|||:|:||..|||||:..|||::||||..||..|:..|..:.
Human   344 HLATNVKIVDWLPQSDLLAHPSIRLFVTHGGQNSVMEAIRHGVPMVGLPVNGDQHGNMVRVVAKN 408

  Fly   406 MAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASH 470
            ....:..|::|.:.||.|:::::|:.||.......|.....:|:||....|.|.::.|:...|:|
Human   409 YGVSIRLNQVTADTLTLTMKQVIEDKRYKSAVVAASVILHSQPLSPAQRLVGWIDHILQTGGATH 473

  Fly   471 MRLNTEDVPLYYEWDWG---------LLLGLRFGIVF--GSVIYLV 505
            ::      |..::..|.         .||||..|.::  |.::.:|
Human   474 LK------PYAFQQPWHEQYLIDVFVFLLGLTLGTMWLCGKLLGVV 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	GT1_Gtf-like	28..458	CDD:340817	111/484 (23%)
UGT3A1	XP_047272663.1	Glycosyltransferase_GTB-type	36..526	CDD:471961	124/540 (23%)