Protein Alignment Ugt303B3 and UGT2A1

DIOPT Version :10

• Sequence 1: NP_651152.1
• Gene: Ugt303B3 / 42774
• FlyBaseID: FBgn0039085
• Length: 539
• Species: Drosophila melanogaster
• Sequence 2: NP_001376494.1
• Gene: UGT2A1 / 10941
• HGNCID: 12542
• Length: 737
• Species: Homo sapiens
• Alignment Length: 565
• Identity: 138/565 - (24%)
• Similarity: 229/565 - (40%)
• Gaps: 147/565 - (26%)

  Fly    30 ILGIFSYHF---------------------SSHNLVVRPLAKALVKRGHNVTLI----------- 62
            |....|||.                     .||.|.::.:.:.|::|.||||::
Human   210 IRNFISYHLQDYMFETLWKSWDSYYSKALDGSHWLNIKIILEELIQRNHNVTVLASSATLFINSN 274

  Fly    63 --TPVGMPTDIEGVRHIRVPKLNQRVQEMIEGDQILDFFGSKWI---ASLMVVSMLYNMSSDILS 122
              :||....       |.|......:..:||...:|      ||   .:.:.:...|.....:|.
Human   275 PDSPVNFEV-------IPVSYKKSNIDSLIEHMIML------WIDHRPTPLTIWAFYKELGKLLD 326

  Fly   123 D---------KGVQK----MLQNRNERFDLVMLEP-------------------------SALEA 149
            .         .||.|    |.:.:...||:::.:|                         |.:|.
Human   327 TFFQINIQLCDGVLKNPKLMARLQKGGFDVLVADPVTICGDLVALKLGIPFMYTLRFSPASTVER 391

  Fly   150 LYG----VVEHYNATL------MGFSGGNVNWSTEEVAGNFAPSINDPISSLGYSRSNSLLSKIY 204
            ..|    .|.:..|.|      |.|.        |.:....:.|:.|.|....:...||..|||
Human   392 HCGKIPAPVSYVPAALSELTDQMTFG--------ERIKNTISYSLQDYIFQSYWGEWNSYYSKI- 447

  Fly   205 NWVHITEEKLLKHLIFRPSQLRIFKKFFNFSEQKFYNMREKYSVILVNNHISMGRVRSNVPNIIE 269
                          :.||:.|              .....|..:.|:..:......|..:||...
Human   448 --------------LGRPTTL--------------CETMGKAEIWLIRTYWDFEFPRPYLPNFEF 484

  Fly   270 VGGLHLTEPAEPCDSKLQKFMDDA-EHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWK 333
            ||||| .:||:|...::::|:..: ::||:.||:|.  ||:.|.|:....:..:|.|..|:|:|:
Human   485 VGGLH-CKPAKPLPKEMEEFIQSSGKNGVVVFSLGS--MVKNLTEEKANLIASALAQIPQKVLWR 546

  Fly   334 TELYNMPNKSDNVYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINL 398
            .:........:|..:.:..||..:|.||.|:.|||:||...:.||:|.|||::|:|:|.||..|:
Human   547 YKGKKPATLGNNTQLFDWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNI 611

  Fly   399 RNVNLRGMAEVLDANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYAL 463
            .::..:|.|..::.|.||...|.|.:|.::..|.|...|.::|:...|:|:.|||.||:|.|:.:
Human   612 AHMKAKGAAVEVNLNTMTSVDLLSALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVM 676

  Fly   464 RNKDASHMRLNTEDVP--LYYEWD-WGLLLGLRFGIVFGSVIYLV 505
            |:|.|.|:|:...|:.  .|:..| .|.||     :...:.|:||
Human   677 RHKGAKHLRVAAHDLTWFQYHSLDVIGFLL-----VCVTTAIFLV 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	GT1_Gtf-like	28..458	CDD:340817	122/513 (24%)
UGT2A1	NP_001376494.1	UDPGT	237..725	CDD:278624	134/538 (25%)