DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and ugt5d1

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001170967.1	Gene:	ugt5d1 / 100415794	ZFINID:	ZDB-GENE-091118-36	Length:	532	Species:	Danio rerio

Alignment Length:	550	Identity:	144/550 - (26%)
Similarity:	250/550 - (45%)	Gaps:	73/550 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVGMPTDIEGV 74
            |:..|||....:..|.....|| ::... .||.:.::.|.:.|..|||::|:|.
Zfish    10 VITGLFLALSAFTLSCSGGKIL-LYPVD-GSHWVNMKVLIEELHSRGHSITVIR----------- 61

  Fly    75 RHIRVPKLNQRVQE-------MIEGDQILDF--FGSKWIASLMVV------------------SM 112
                 ||.:..:.|       :...|.:.||  |...:::..|.:                  ||
Zfish    62 -----PKSSWYITEKSPLYTSITIQDNVNDFENFFEDYLSKAMEIERGEGSGLAFLKLQYDLFSM 121

  Fly   113 L-------YNMSSDILSDKGVQKMLQNRNERFDLVMLEPSALEALYGVVEHYNATLMGFSGGNVN 170
            |       ..|.|.||.||.:.|.||  :|::||::.:|:....::  :.||....:..   ||.
Zfish   122 LSTAHEIACKMVSIILEDKMLVKKLQ--DEQYDLMLTDPAIAGGVF--LAHYLKLPLVL---NVR 179

  Fly   171 WSTEEVAGNFA----PSINDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRIFKKF 231
            |.|.. .|:||    |....|:...|::.......::.|.:..|...|....:..|....:..|:
Zfish   180 WITSG-EGHFAIAPSPMSYIPLPGSGHTDKMGFAQRVKNVLFKTFTFLQNRFVVGPHYDILIDKY 243

  Fly   232 FNFSEQKFYNMREKYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKF-MDDAEH 295
            .:: :.....:.:...:.|:.........|..:|||:.:||.. .:|::|..:.|:.| ....||
Zfish   244 LDY-KTDIVGLIQAADIWLMRADFVFEFPRPTMPNIVYMGGFR-CKPSKPLPADLEAFAQSSGEH 306

  Fly   296 GVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMP-NKSDNVYVIEQPPQRAVLA 359
            |.|..|:|  .:|:.||.||...:..:..:..|:|:|: .|.:.| |..:|..:::..||..:|.
Zfish   307 GFIIMSLG--TLVKSLPADMANAIAAAFARLPQKVIWR-HLGDRPSNVGNNTLIVDWMPQNDLLG 368

  Fly   360 HPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTI 424
            |...:.|:.:||...|.||::.|||:||:|:|||||.||..|..:|..::|..:|:..|.....:
Zfish   369 HSKIKAFVAHGGTNGVQEAIFHGVPVLGVPLFFDQFDNLIRVQGKGAGKILKLSELNAEAFEQAL 433

  Fly   425 RKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLNTEDVP--LYYEWDWG 487
            |:.|.:..|....:.:|...||:||.|||||::|.|:.:|:|.|:|:|.....:|  .|:..|..
Zfish   434 RESLNDGSYKRNMQTLSTLHRDQPMRPLDTAIFWIEHVIRHKGATHLRSEFYKMPWYSYHSVDVF 498

  Fly   488 LLLGLRFGIVFGSVIYLVYKLFQKTSARRR 517
            |:|.:...:...|.|.::..:..|...||:
Zfish   499 LVLFIVAAVCMLSTIAVIRYVCYKICCRRK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	130/495 (26%)
ugt5d1	NP_001170967.1	UDPGT	28..527	CDD:278624	137/529 (26%)
ugt5d1	NP_001170967.1	egt	<267..506	CDD:223071	81/242 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585154
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.690