DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt303B3 and ugt1b3

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001170817.1	Gene:	ugt1b3 / 100384903	ZFINID:	ZDB-GENE-080227-12	Length:	535	Species:	Danio rerio

Alignment Length:	531	Identity:	141/531 - (26%)
Similarity:	237/531 - (44%)	Gaps:	89/531 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHLEFYWLAVLFCLF--------LQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGH 57
            ||     |.|:|||.        :.:.|.:.|.....:|.:  ....||...|:.:|:.:.:|||
Zfish     5 MH-----LGVIFCLVVGVVCSAAVDQKLSRKSSWTGKLLVV--PMDGSHWTGVKAVAEEMGRRGH 62

  Fly    58 NVTLITP-VGMPTDIEGVRHIRVPK-------------LNQRVQEMIE-GDQILDFFGSKWIASL 107
            .|.::.| :.|  .:...:|....|             |.:.|.|:.. |...|....|.....|
Zfish    63 TVIVVIPEISM--RLGPGKHYITKKFPVKYDQKLFNEVLTEHVHEVTNPGHSRLKTVTSTMANLL 125

  Fly   108 MVVSMLYNMSSDILSDKGVQKMLQNRNERFDLVMLEPSALEALYGVVEHYNATLMG---FSGGNV 169
            .:.:|:.:.|..:..||.:.|.|  |:|.||.::.:| ||.  .|.|..||.::..   ..|...
Zfish   126 KMFNMMASTSESLFQDKELIKFL--RDENFDAILTDP-ALP--MGAVLAYNFSVPAVYMLRGMPC 185

  Fly   170 NWSTEEVAGNFAPSI-------NDPISSLGYSRSNSLLSKIYNWVHITEEKLLKHLIFRPSQLRI 227
            .......|....||.       |....|.|....|.|:|       |.|:...|.:
Zfish   186 ALDATATACPNTPSYIPRFHTGNTDRMSFGERVMNVLMS-------ILEQVACKVM--------- 234

  Fly   228 FKKFFNFSE------QKFYNMREKYS---VILVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCD 283
               :::|.|      |:..::.|..|   |.|:....::...:..:||:..:||:: .....|..
Zfish   235 ---YWSFEEVTPNFLQRDVSLTEILSTGAVWLMRYDFTLEFPKPLMPNMQFIGGIN-CGVKNPLM 295

  Fly   284 SKLQKFMD-DAEHGVIYFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWK--TELYNMPNKSDN 345
            .::::|:: ..|||::.||:|.  :|..:|::......|:.....|||:|:  .|:.|  |..:|
Zfish   296 KEVEEFVNGSGEHGIVVFSLGS--LVSSMPKEKADIFFKAFSMIPQRVLWRYTGEIPN--NVPEN 356

  Fly   346 VYVIEQPPQRAVLAHPNTRLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVL 410
            |.:::..||..:|..|..|.|||:||...:.|.:..|||::.||:|.||..|:..|..||:..:|
Zfish   357 VKLMKWLPQNDLLGPPKARAFITHGGTHGIYEGICHGVPMVMLPLFGDQADNVHRVATRGVGVIL 421

  Fly   411 DANEMTLEILTSTIRKLLENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLNT 475
            ..:::|:|.|...:..::.|..|..|.:|:|....|||:.|||.||:|||:.:|:|.|.|:|
Zfish   422 SIHDITVETLLDALNSVINNSSYKQKMQKLSAIHNDRPIQPLDLAVFWTEFVMRHKGADHLR--- 483

  Fly   476 EDVPLYYEWDW 486
               |..:|.:|
Zfish   484 ---PAAHELNW 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	132/503 (26%)
ugt1b3	NP_001170817.1	UDPGT	35..516	CDD:278624	132/496 (27%)
ugt1b3	NP_001170817.1	egt	<275..514	CDD:223071	75/228 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584717
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.830