DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt303B3 and ugt2a3

DIOPT Version :9

Sequence 1:	NP_651152.1	Gene:	Ugt303B3 / 42774	FlyBaseID:	FBgn0039085	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	NP_001170814.2	Gene:	ugt2a3 / 100384900	ZFINID:	ZDB-GENE-080721-22	Length:	532	Species:	Danio rerio

Alignment Length:	551	Identity:	156/551 - (28%)
Similarity:	255/551 - (46%)	Gaps:	72/551 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 AVLFCLFLQKDLYQDSVQAANILGIFSYHFSSHNLVVRPLAKALVKRGHNVTLITPVGMPTDIEG 73
            |:|.||.|   ...|...:..:|.:...:...||:  |.:.:|||.|.|:||::.....||
Zfish     5 ALLVCLLL---CGVDVGWSGRVLVMPGEYSHWHNM--RAIIEALVDRNHSVTVLVGSSSPT---- 60

  Fly    74 VRHIRVPKLNQRV----QEMIEGDQILDFFGSKWI----ASLMVVSMLYNMSSDI--LSD---KG 125
            |.|.:..:.:..|    .|..|.|.:...|...|:    .....||.::.:.|..  |:|   ||
Zfish    61 VPHTQKARFDYHVFKVNIEKEEADAVWSDFIYLWMNETATKYETVSNIFQVMSRFMTLTDEVCKG 125

  Fly   126 VQK--MLQN-RNERFDLVMLEP----SALEALYGVVEHYNATLMGFSGGNVNWSTEEVAGNF-AP 182
            :.|  :||. |...:|::..:|    |.|.|     :..|..|:........:|.|.:.|.. ||
Zfish   126 MFKEDLLQMLRESHYDVLFSDPMMPCSDLMA-----QTLNIPLVLSLRATFAYSFERMCGQMPAP 185

  Fly   183 SINDPISSLGYSRSNSLLSKIYNWVHITEEKLL--KHLIFRPSQLRIFKKFFNFSEQKFY----- 240
            ....|.:||     ...|:...:::...|..||  .|.:|       ||.:..|:..:.|
Zfish   186 PSYVPAASL-----RDHLTDRMSFMERVENMLLYFSHDVF-------FKLYMMFTFDRIYTEIRG 238

  Fly   241 ---NMRE---KYSVILVNNHISMGRVRSNVPNIIEVGGLHLTEPAEPCDSKLQKFMDDA-EHGVI 298
               .|.|   |..:.|:..:......|...||...||||| .:||:|...::::|:..: :|||:
Zfish   239 KPTTMCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLH-CKPAKPLSKEMEEFVQSSGDHGVV 302

  Fly   299 YFSMGQEIMVQFLPEDMQQNLMKSLDQFKQRVVWKTELYNMPNKSDNVYVIEQPPQRAVLAHPNT 363
            .||:|.  |::.|..:....:..:|.|..|:|||:.........:.|..:.:..||..:|.||.|
Zfish   303 VFSLGS--MIKNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKT 365

  Fly   364 RLFITNGGLLSVMEAVYSGVPILGLPVFFDQFINLRNVNLRGMAEVLDANEMTLEILTSTIRKLL 428
            :.|||:||...:.||:|.|||::|||:|.||..||.::..:|.|.|||.|.:..:.|...::.:|
Zfish   366 KAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVL 430

  Fly   429 ENPRYALKAKKMSQSFRDRPMSPLDTAVWWTEYALRNKDASHMRLNTEDVPLYYEWDW----GLL 489
            .||.|.....::|:...|:||.|||.||:|.|:.:|||.|.|:|:...::. :|::..    ..|
Zfish   431 NNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELS-WYQYHCLDVAAFL 494

  Fly   490 LGLRFGIVF---GSVIYLVYKLFQKTSARRR 517
            |.:...|.|   .:..:|..:..:||...|:
Zfish   495 LSIAALITFLWVKACCFLFRRCVRKTRPERK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt303B3	NP_651152.1	egt	7..466	CDD:223071	142/491 (29%)
ugt2a3	NP_001170814.2	UDPGT	21..519	CDD:278624	147/524 (28%)
		REC	<129..>178	CDD:302758	12/53 (23%)
		egt	<254..485	CDD:223071	82/234 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585024
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930