DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG10175 and CES2

DIOPT Version :9

Sequence 1:NP_001287487.1 Gene:CG10175 / 42773 FlyBaseID:FBgn0039084 Length:707 Species:Drosophila melanogaster
Sequence 2:NP_001352334.1 Gene:CES2 / 8824 HGNCID:1864 Length:559 Species:Homo sapiens


Alignment Length:583 Identity:171/583 - (29%)
Similarity:260/583 - (44%) Gaps:119/583 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   155 VATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSC- 218
            :.||..|:|.|.....: |...|..:|.|:.:..||.|..||...||.:.|||:||.:.....| 
Human    33 IRTTHTGQVLGSLVHVK-GANAGVQTFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCL 96

  Fly   219 -----------PHKNMILDTFKGD---EDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSF 269
                       ...||   ||..|   ||||:::::|..     .|.|...||||||:|||...|
Human    97 QDLTAVESEFLSQFNM---TFPSDSMSEDCLYLSIYTPA-----HSHEGSNLPVMVWIHGGALVF 153

  Fly   270 GSGNSFLYGPDYLVA-EDIVLVTLNYRLGPLGFLTAG-PDAPGNQGLKDQVLALKWVRDNIAAFG 332
            |..:  ||....|.| |::|:|.:.||||.|||.:.| ..|.||.|..|||.||:||:.|||.||
Human   154 GMAS--LYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNWGYLDQVAALRWVQQNIAHFG 216

  Fly   333 GDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYV 397
            |:|::|||||||||.:||..|::|..::||||.||.:||.||.| .:.|||:...:.:.|||...
Human   217 GNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLP-GLIASSADVISTVVANLSAC 280

  Fly   398 GANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPF--VP-VVEGYWNQDSQEEQFYEEP 459
            ....:|.::..||.              .::::...|..||  :| ||:|.              
Human   281 DQVDSEALVGCLRG--------------KSKEEILAINKPFKMIPGVVDGV-------------- 317

  Fly   460 FLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQDLNVTESH 524
            ||.:||.::..|.:|                      :..|.::.:..|:||.|:|:.:.:.::.
Human   318 FLPRHPQELLASADF----------------------QPVPSIVGVNNNEFGWLIPKVMRIYDTQ 360

  Fly   525 DRVTRE----------------------IRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRRTAR 567
            ..:.||                      :|..|:|..........:...::.|.||:....:.| 
Human   361 KEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQVA- 424

  Fly   568 NHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPGVCHGDELGYLFKFGFFNLSLDPKSMEVQVKN 632
             |.:...||||.|.|....|   :.:.:..|.....|||||.::|:..|....:.....|.|:..
Human   425 -HFQCSRAPVYFYEFQHQPS---WLKNIRPPHMKADHGDELPFVFRSFFGGNYIKFTEEEEQLSR 485

  Fly   633 RMVRMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFW 695
            :|::.|.|||:.|:|..:.     ...|...|...     .|:.::...|:....:..|.:||
Human   486 KMMKYWANFARNGNPNGEG-----LPHWPLFDQEE-----QYLQLNLQPAVGRALKAHRLQFW 538

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10175NP_001287487.1 COesterase 157..695 CDD:278561 169/579 (29%)
CES2NP_001352334.1 COesterase 30..538 CDD:306613 169/581 (29%)
Prevents secretion from ER. /evidence=ECO:0000255 556..559
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG1516
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 216 1.000 Inparanoid score I3612
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000017
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100080
Panther 1 1.100 - - O PTHR11559
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
76.860

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