DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10175 and Ces2j

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	XP_038953911.1	Gene:	Ces2j / 685645	RGDID:	1591368	Length:	576	Species:	Rattus norvegicus

Alignment Length:	596	Identity:	177/596 - (29%)
Similarity:	275/596 - (46%)	Gaps:	107/596 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 RSLRKERE-----------------------IVATTSLGKVRGRYQKYRSGERGGYYSFKGMRYG 187
            :.||:|||                       .:..|..|:|||.:...:. .:.|.::|.|:.:.
  Rat    21 KGLRRERERKKGIPDSNLHSFLTEQGQDSASPIRNTHTGQVRGSFVHVKD-TKSGIHTFLGIPFA 84

  Fly   188 APPTGARRFRAAEPEKPWSGIRDASREGQSCPHKNMI---------LDTFKGDEDCLFVNVFTTQ 243
            .||.|..||...|..:||||:|||:.:...|....|:         |......||||::|::...
  Rat    85 KPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTAMMNLEGMKETELTKLPMSEDCLYLNIYVPA 149

  Fly   244 MPKDDESAEQPKLPVMVWLHGGGFSFGSGNSFLYGPDYLVA-EDIVLVTLNYRLGPLGFLTAGPD 307
            ...:|.:     ||||||:||||...||.:  :.....|.| |:||:|::.||||.|||.:.|..
  Rat   150 HAHEDSN-----LPVMVWIHGGGLVGGSAS--MNDASTLAATEEIVIVSIQYRLGVLGFFSTGDQ 207

  Fly   308 -APGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSG 371
             |.||.|..||:.||:||:.|||.|||:.:.|||||.|||.:||...::|..:||||||||.|||
  Rat   208 HARGNWGYLDQMAALRWVQQNIAYFGGNRDSVTIFGVSAGGTSVSSHVVSPMSKGLFHRAIMQSG 272

  Fly   372 SALNPWSMSASSSQRAARLAANLGYVGANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGL 436
            .||.| .:.:.:|:...:..|||....|:.:|.::..||.....:::..            |...
  Rat   273 VALLP-GLISDTSEVVYKTVANLSGCEASDSEALIRCLRAKSKQEILAI------------NQVF 324

  Fly   437 PFVP-VVEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNP 500
            ..:| ||:|              .||.:||.::..|::|: .|..:.|.||.|....:      |
  Rat   325 KMIPGVVDG--------------KFLPKHPQELLASKDFH-PVPSIIGVNTDECGWGV------P 368

  Fly   501 QLLS---IIENDFGRLVPQDLNVTESHDRVTRE----IRSFYLGSKHVGIESVDEMIA----LLT 554
            .:|.   ||.|.....:|..|.:..:...:..|    |...|:|.    .|..:.:.|    :|.
  Rat   369 TILGLYHIINNITRETLPAALKIAAAQMMLPPECIDLIMEEYMGD----TEDAETLQAQFKEMLG 429

  Fly   555 DLMFLQGIRRTARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPGVCHGDELGYLFKFGFFNL 619
            |.:|:....:.|  |.:...||||.|.|..  .|...|::... .|...|||:..::|...|:.:
  Rat   430 DFIFVIPALQVA--HFQRSQAPVYFYEFQH--LLSFIKQVRPF-YPKADHGDDTVFVFGSYFWGM 489

  Fly   620 SLDPKSMEVQVKNRMVRMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDISANLAMK 684
            :.|....|..:|.|:::.|.|||:.|:  |:.||   ...|..:|     :...|:.:::..|:.
  Rat   490 TFDLTEEEELLKRRVMKYWANFARTGN--PNGED---LPHWPVLD-----HDEQYLQLNSQPAVG 544

  Fly   685 TNPEPERQRFW 695
            ...:..|.:||
  Rat   545 RALKARRLQFW 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	170/560 (30%)
Ces2j	XP_038953911.1	COesterase	50..555	CDD:395084	170/565 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.820