DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10175 and LOC679149

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001094469.1	Gene:	LOC679149 / 679149	RGDID:	1591847	Length:	561	Species:	Rattus norvegicus

Alignment Length:	606	Identity:	165/606 - (27%)
Similarity:	269/606 - (44%)	Gaps:	133/606 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 EREIVATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREG 215
            |...:..|.:|:|||:....:. .:.|.::|.|:.:..||.|..||...|..:||||:||.:.:.
  Rat    31 ESSPIRNTHIGQVRGKLDHVKD-TKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTSQP 94

  Fly   216 QSCPHKNMILDTFKGD---------------EDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGG 265
            ..|...   ||....:               ||||::|::...     .:.|...||||||:|||
  Rat    95 AMCLQN---LDVINAEGLKEMKLKLPPVSMSEDCLYLNIYAPA-----HAHEGSNLPVMVWIHGG 151

  Fly   266 GFSFGSGNSFLYGPDYL-VAEDIVLVTLNYRLGPLGFLTAGPD-APGNQGLKDQVLALKWVRDNI 328
            |..  :|.:.:|....| |.||:|:||:.||||.|||.:.|.: |.||.|..|||.||:||:.||
  Rat   152 GLM--TGMASMYDGSLLTVNEDLVVVTIQYRLGVLGFFSTGDEHARGNWGYLDQVAALRWVQQNI 214

  Fly   329 AAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAAN 393
            |.|||:|::|||||||||.:.|...::|..::||||.||.:||.||.|: :.|.:|:..:.:.|.
  Rat   215 AHFGGNPDRVTIFGESAGGTCVSTHVVSPMSQGLFHGAIMESGVALLPY-LIADTSEMFSTMVAK 278

  Fly   394 LGYVGANKTEDILDFLRR------VPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQE 452
            :....|..:|.::..||.      :...|:|:..|..:..|
  Rat   279 VSGCEAMDSEALVHCLRAKSEAEILAINKVVQMVPAVVDGE------------------------ 319

  Fly   453 EQFYEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQD 517
                   ||.:||.::..|::|                      |..|.::.:..:::|..:|..
  Rat   320 -------FLPRHPKELLASEDF----------------------RPVPSIIGVNNDEYGWTIPLV 355

  Fly   518 LNVTESHDRVTRE----------------------IRSFYLGSKHVGIESVDEMIALLTDLM--F 558
            :..|:....::||                      :...|:|.    ||....:.|..|:||  |
  Rat   356 MGTTQMIKELSRENLQAILKKTTAQLMLPLECSDLLMEEYMGD----IEDPKTLQAQFTELMEDF 416

  Fly   559 LQGIRRTARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPGVCHGDELGYLFKFGFFNLSLDP 623
            :..|......|.:..:||||.|.|....:   :.:.:..|.....||||:.::|.:.|:::..|.
  Rat   417 MFVIPALQVAHFQCSHAPVYFYEFQHQIT---FLKDIRPPHVKADHGDEIPFVFGYFFWDMKTDF 478

  Fly   624 KSMEVQVKNRMVRMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDISANLAMKTNPE 688
            ...|..:..||::.|.|||::|:|..:.     .:.|..:|     :...|:.:....|:....:
  Rat   479 TEEEKLLSRRMMKYWANFARHGNPNSEG-----LSYWPVMD-----HDQQYLQLDTQPAVGRALK 533

  Fly   689 PERQRFW----DEMYQHYNGA 705
            ..|.:||    .:..|...||
  Rat   534 ARRLQFWTKTLPQKIQELKGA 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	159/584 (27%)
LOC679149	NP_001094469.1	COesterase	31..540	CDD:278561	160/590 (27%)
LOC679149	NP_001094469.1	Aes	<130..>233	CDD:223730	54/109 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810