DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10175 and cel.2

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001020344.2	Gene:	cel.2 / 565117	ZFINID:	ZDB-GENE-061110-10	Length:	551	Species:	Danio rerio

Alignment Length:	558	Identity:	167/558 - (29%)
Similarity:	261/558 - (46%)	Gaps:	96/558 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 FKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCPHKNMILDTFKGDEDCLFVNVFTTQMP 245
            |||:.:.|||   .|.:...|...|.|:..|:...:.|...|::.....|.||||::|::..|
Zfish    49 FKGIPFAAPP---GRLQKPVPHPGWEGVLKATEYSKRCIQLNLLQTDTMGSEDCLYLNIWVPQ-- 108

  Fly   246 KDDESAEQPKLPVMVWLHGGGFSFGSG------NSFLY-GPDYLVAEDIVLVTLNYRLGPLGFLT 303
               .......|||||:::||||..|.|      :::|| |.:.....::::||.|||:|.:|||:
Zfish   109 ---GKTVSYNLPVMVFIYGGGFLLGGGQGANFLDNYLYDGEEIADRGNVIVVTFNYRVGSMGFLS 170

  Fly   304 AG-PDAPGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAI 367
            .| .|||||.||.||..|:.||..||.||||:|:.:||||||||::||...::|.:.|||..|||
Zfish   171 TGDADAPGNYGLWDQHAAISWVHRNIKAFGGNPDNITIFGESAGSTSVNFQIISPKNKGLIRRAI 235

  Fly   368 SQSGSALNPWSMSASSSQRAARLAANLGYVGANKTEDILDFLRRVPAMKLVEAAP---TTITAED 429
            ||||.||.||:::.:..:.|..:|..   ||......::..|||.....:..|..   .|...|.
Zfish   236 SQSGVALCPWAINRNPRKFAEEIAKK---VGCPTDSGMVACLRRTDPKAVTLAGKVRLATSATEP 297

  Fly   430 QRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLF-- 492
            ..:|:.|.  ||::|              .|:...|..::.:.   :|:.|:.|.|..:..:|
Zfish   298 IVHNLYLS--PVIDG--------------DFIPDEPDTLFGNA---ADIDYIAGVNDMDGHIFAT 343

  Fly   493 --IRRLRKNPQLLSIIENDFGRLVPQDLNVTESHDR------VTREIRSFYLGSKHVGIESVDEM 549
              |..:  |..|.:..|.:.     |.|....|.||      .|.:..:...|||....:....:
Zfish   344 LDIPSI--NNALATTTEEEV-----QALATALSKDRGQDAGIATFQEYTVNWGSKPNKEDIKKTV 401

  Fly   550 IALLTDLMFLQGIRRTARNH---AKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPGVCHGDELGYL 611
            :.:.||.:||...:.....|   ||  :|..|.|.||....:.::...:|..     |.|||.|:
Zfish   402 VEMETDYIFLVPTQTALYLHSDNAK--SARTYSYLFSESSRIPIFPLWMGAD-----HADELQYV 459

  Fly   612 F------KFGFFNLSLDPKSMEVQVKNRMVRMWTNFAKYGSP-TPDSEDPMLTTKWAPIDPTNVM 669
            |      ..|:|     |:..:  |...|:..|||||:.|:| |.:|:.|:...:::  :|.:
Zfish   460 FGKPFTTPLGYF-----PRHRD--VSKYMIAYWTNFAQTGNPNTGESKVPVTWPEFS--NPGH-- 513

  Fly   670 NSLNYMDISANLAMKTNPEPERQR-----FWDEMYQHY 702
               .|:||  |..:.||...:..|     :|..::..|
Zfish   514 ---QYLDI--NNKINTNSVKKMLRTRLVYYWTTVFASY 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	165/549 (30%)
cel.2	NP_001020344.2	COesterase	26..539	CDD:306613	165/549 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720