DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10175 and NLGN3

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_851820.1	Gene:	NLGN3 / 54413	HGNCID:	14289	Length:	848	Species:	Homo sapiens

Alignment Length:	652	Identity:	190/652 - (29%)
Similarity:	283/652 - (43%)	Gaps:	170/652 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 TSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCPHK- 221
            |..||:||......|...|....:.|:.|.|||.|.:||...||...|||||:|:.....||..
Human    46 THFGKLRGARVPLPSEILGPVDQYLGVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNI 110

  Fly   222 ---------------NM-ILDTF--KGDEDCLFVNVFTTQMPKDD------ESAEQPK------- 255
                           |: |:.|:  :.:||||::||:   :|.:|      |.|.:|.
Human   111 HTAVPEVMLPVWFTANLDIVATYIQEPNEDCLYLNVY---VPTEDVKRISKECARKPNKKICRKG 172

  Fly   256 ---------------------------LPVMVWLHGGGFSFGSGN----SFL--YGPDYLVAEDI 287
                                       .||||::|||.:..|:||    |.|  ||       ::
Human   173 GSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGNMIDGSILASYG-------NV 230

  Fly   288 VLVTLNYRLGPLGFLTAGPD-APGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAGASSVQ 351
            :::|||||:|.||||:.|.. |.||.||.||:.||:||.:|||.|||||.::|:||...|||.|.
Human   231 IVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFFGGDPRRITVFGSGIGASCVS 295

  Fly   352 LLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYVGAN--KTEDILDFLRRVPA 414
            ||.||..::|||.|||.||||||:.|:::....:..:.||..   ||.|  .|.|::|.||:..|
Human   296 LLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADK---VGCNVLDTVDMVDCLRQKSA 357

  Fly   415 MKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFNSDVA 479
            .:|||       .:.|.....:.|.||::|....|..|....:..||             |.|:
Human   358 KELVE-------QDIQPARYHVAFGPVIDGDVIPDDPEILMEQGEFL-------------NYDI- 401

  Fly   480 YMTGYNTHEAMLFIRRLRKNPQ-----------LLSIIENDFGRLVPQDLNVTESHDRVTREIRS 533
             |.|.|..|.:.|:..: .:|:           :.:.::|.:|        ..|..|.:...|:.
Human   402 -MLGVNQGEGLKFVEGV-VDPEDGVSGTDFDYSVSNFVDNLYG--------YPEGKDTLRETIKF 456

  Fly   534 FYLGSKHVGIESVDE---------MIALLTDLMFLQGIRRTARNHAKFGNAPVYMYRFSFDGSLG 589
            .|       .:..|.         ::||.||..:::....||..||::| :|.|.|.|
Human   457 MY-------TDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLHARYG-SPTYFYAF------- 506

  Fly   590 LYKRMLGIPRPG---VCHGDELGYLFKFGFFN-LSLDP---KSMEVQVKNRMVRMWTNFAKYGSP 647
             |.....:.:|.   ..||||:.|:|...... ..|.|   ...:|.:...::..||||||.|.|
Human   507 -YHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDP 570

  Fly   648 T-PDSED-PMLTTK--------WAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFWDEMYQH- 701
            . |..:| ..:.||        |:..:|.:.:    |:.|.....::.:....:..||..:..|
Human   571 NKPVPQDTKFIHTKANRFEEVAWSKYNPRDQL----YLHIGLKPRVRDHYRATKVAFWKHLVPHL 631

  Fly   702 YN 703
            ||
Human   632 YN 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	185/641 (29%)
NLGN3	NP_851820.1	COesterase	36..624	CDD:278561	185/641 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	170..195		0/24 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..694
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810