DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10175 and Cesl1

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	XP_038953870.1	Gene:	Cesl1 / 501232	RGDID:	1565666	Length:	596	Species:	Rattus norvegicus

Alignment Length:	597	Identity:	166/597 - (27%)
Similarity:	257/597 - (43%)	Gaps:	110/597 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCP 219
            |..|..|||.|:|... .|.......|.|:.:..||.|:.||...:|.:|||.:::.:.....|.
  Rat    60 VVDTMKGKVLGKYASL-EGVTQSVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTTYPPMCS 123

  Fly   220 HKNMILDTFKG------------------DEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGG 266
            .     |..||                  .||||::|::|   |.|  ..:..::|||||:||||
  Rat   124 Q-----DATKGQRMNDLLTNRKEKVHLQFSEDCLYLNIYT---PAD--FTKDSRMPVMVWIHGGG 178

  Fly   267 FSFGSGNSFLYGPDYLVA-EDIVLVTLNYRLGPLGFLTAGPD-APGNQGLKDQVLALKWVRDNIA 329
            .:.|..::  |....|.| |::|:|.:.||||..||.:.|.: :.||.|..|||.||.||:||||
  Rat   179 LTQGGAST--YDGQVLSAYENVVVVAIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALHWVQDNIA 241

  Fly   330 AFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANL 394
            .|||||..|||||||||..||.:|:||..:|.|:|||||:||..|.. .:.....:.||:..|::
  Rat   242 NFGGDPGSVTIFGESAGGFSVSVLVLSPLSKNLYHRAISESGVVLIT-ELFTKDVRPAAKQIADM 305

  Fly   395 GYVGANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFY--- 456
            .......:..|:..||:....:|:|..       ::.|.|.|..        .:|::|...:
  Rat   306 AGCKTTTSAIIVHCLRQKTEEELLEIM-------EKMNLIKLSS--------QRDTKESYHFLST 355

  Fly   457 --EEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQDLN 519
              ::..|.:.|.::...:|||: |.|:.|.|..|....:      |.::        |.||.|:.
  Rat   356 VIDDVVLPKDPKEILAEKNFNT-VPYIVGINKQECGWLL------PTMM--------RFVPPDVK 405

  Fly   520 VTES----------------HDRVTREIRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRRTARN 568
            :.:.                .|.:...|..:..||.. .|:..|.::|.:.|.:|.......:|:
  Rat   406 LDKKMAIMLLEKFASIYGIPEDIIPVAIEKYRKGSDD-PIKIRDGILAFIGDALFCIPSVMVSRD 469

  Fly   569 HAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPGVCHGDELGYLFK-FGFFNLSLDPKSMEVQVKN 632
            |...| ||.|:|.:.:      |.......||....||....::. ||...|.......|:::..
  Rat   470 HRDAG-APTYVYEYQY------YPSFSSPQRPKDVVGDHADDVYSVFGAPILRDGASEEEIKLSK 527

  Fly   633 RMVRMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFWDE 697
            .:::.|.|||:.|:|....     ...|...|...     .|:.|.|........:.|...||.:
  Rat   528 MVMKFWANFARNGNPNGRG-----LPHWPQYDQKE-----EYLQIGATTQQSQGLKAEEVAFWTQ 582

  Fly   698 M------YQHYN 703
            :      ..|:|
  Rat   583 LLAKRQPQPHHN 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	161/579 (28%)
Cesl1	XP_038953870.1	COesterase	57..580	CDD:395084	162/581 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.000