DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10175 and Ces2h

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001258974.1	Gene:	Ces2h / 436059	MGIID:	3648740	Length:	558	Species:	Mus musculus

Alignment Length:	584	Identity:	157/584 - (26%)
Similarity:	253/584 - (43%)	Gaps:	121/584 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCP 219
            :.||..|::.|.....:..: .|.:||.|:.:..||.|..||...||.:||.|:||.:.....|.
Mouse    32 IRTTHTGQILGSLIHMKDLD-VGVHSFLGIPFAKPPVGPLRFAPPEPPEPWGGVRDGTSHPAMCL 95

  Fly   220 HK------------NMILDTFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSG 272
            ..            .:.|..|...||||::|::.     .|.:.|...||||||:|||....|..
Mouse    96 QDITAMNMQAFKLLKLTLPPFPMSEDCLYLNIYA-----PDHAHEGSNLPVMVWIHGGSLVIGMA 155

  Fly   273 NSFLYGPDYLVA-EDIVLVTLNYRLGPLGFLTAGPD-APGNQGLKDQVLALKWVRDNIAAFGGDP 335
            :  :|....|.| |::|:||:.||||.|||.:.|.: |.||.|..|||.||:|::.|||.|||:|
Mouse   156 S--MYDGSMLAAMENVVVVTIQYRLGVLGFFSTGDERARGNWGYLDQVAALRWLQQNIAYFGGNP 218

  Fly   336 NQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYVGAN 400
            ::|||||.|||.:||..|::|..::|||..||.:||.||.. |:.:.||....:..|||......
Mouse   219 DRVTIFGTSAGGTSVSSLVVSPMSQGLFRGAIMESGVALIS-SLISVSSDVVYQTVANLSGCEQV 282

  Fly   401 KTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVP-VVEGYWNQDSQEEQFYEEPFLTQH 464
            .:|.:::.||.....:::..            |.....:| :|:|.              ||.:|
Mouse   283 DSEALVNCLRGKSEEEIMAI------------NKAFKIIPGIVDGI--------------FLPRH 321

  Fly   465 PSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQDLNVTESHDRVTR 529
            |.::..|.:|            |..          |.::.:..:::|.::|..:::.:|...:.|
Mouse   322 PQELMASADF------------HPV----------PSIIGVNNDEYGWIIPSSMSMIDSKKGMDR 364

  Fly   530 EIRSFYLGSKHVGIESVDEMIALL--------TDLMFLQ-----------------GIRRTARNH 569
            ::....|..:...:....|:..||        .|..|||                 .:.:..|:|
Mouse   365 QMVQAILQRRATQMMWPPEVSDLLMEEYMGDNEDPQFLQVQFKEMMKDFTFVIPALQVAQFQRSH 429

  Fly   570 AKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPG---VCHGDELGYLFKFGFFNLSLDPKSMEVQVK 631
                 |||:.|.|....|  .:|.    .:|.   ..||||:.::|:..:....:|....|..:.
Mouse   430 -----APVFFYEFQHRPS--FFKD----SKPSHVKADHGDEILFIFRSFWGGTQVDFTEEEELLS 483

  Fly   632 NRMVRMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFW 695
            .||::.|.|||:..:|..:.     ...|...|...     .|:.:....|:....:..|.:||
Mouse   484 RRMMKYWANFARQRNPNSEG-----LPYWPMFDQDE-----QYLQLDTQPAVGRALKTRRLQFW 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	155/580 (27%)
Ces2h	NP_001258974.1	COesterase	30..537	CDD:278561	155/582 (27%)
Ces2h	NP_001258974.1	Aes	<127..>230	CDD:223730	51/109 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.810