Protein Alignment CG10175 and ACHE

DIOPT Version :9

• Sequence 1: NP_001287487.1
• Gene: CG10175 / 42773
• FlyBaseID: FBgn0039084
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_001354847.1
• Gene: ACHE / 43
• HGNCID: 108
• Length: 681
• Species: Homo sapiens
• Alignment Length: 635
• Identity: 195/635 - (30%)
• Similarity: 280/635 - (44%)
• Gaps: 142/635 - (22%)

  Fly   149 RKEREIVATTSLGKVRGRYQKYRSGERGGYYS-FKGMRYGAPPTGARRFRAAEPEKPWSGIRDAS 212
            |::.|::.|...|::||    .|....||..| |.|:.:..||.|.|||...||::||||:.||:
Human   101 REDAELLVTVRGGRLRG----IRLKTPGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDAT 161

  Fly   213 REGQSC-PHKNMILDTFKG----------DEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGG 266
            .....| .:.:.:...|:|          .||||::||: |..|:.....     ||:||::|||
Human   162 TFQSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVW-TPYPRPTSPT-----PVLVWIYGGG 220

  Fly   267 FSFGSGNSFLYGPDYLV-AEDIVLVTLNYRLGPLGFLT--AGPDAPGNQGLKDQVLALKWVRDNI 328
            |..|:.:..:|...:|| ||..|||::|||:|..|||.  ...:||||.||.||.|||:||::|:
Human   221 FYSGASSLDVYDGRFLVQAERTVLVSMNYRVGAFGFLALPGSREAPGNVGLLDQRLALQWVQENV 285

  Fly   329 AAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPW-SMSASSSQRAARLAA 392
            |||||||..||:|||||||:||.:.|||..::||||||:.|||:...|| ::....::|.|...|
Human   286 AAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWATVGMGEARRRATQLA 350

  Fly   393 NL-----GYVGANKTEDILDFLRRVPAMKLV----EAAPTTITAEDQRNNIGLPFVPVVEGYWNQ 448
            :|     |..|.|.|| ::..||..||..||    ...|       |.:.....|||||:|
Human   351 HLVGCPPGGTGGNDTE-LVACLRTRPAQVLVNHEWHVLP-------QESVFRFSFVPVVDG---- 403

  Fly   449 DSQEEQFYEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFI-----RRLRKNPQLLSIIEN 508
                      .||:..|..:.::.:|:. :..:.|....|...|:     ...:.|..|:|..|
Human   404 ----------DFLSDTPEALINAGDFHG-LQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAE- 456

  Fly   509 DFGRLVPQDLNVTESHDRVTREIRSFYLGSKH--------------VGIESVDEMIALLTDLMFL 559
               .|....:.|.:..|.....:...|....|              ||..:|...:|.|...:..
Human   457 ---FLAGVRVGVPQVSDLAAEAVVLHYTDWLHPEDPARLREALSDVVGDHNVVCPVAQLAGRLAA 518

  Fly   560 QGIRRTARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPGVCHGDELGYLFKFGFFNLSLDPK 624
            ||.|             ||.|.|....|...:...:|:|     ||.|:.::     |.:.|||.
Human   519 QGAR-------------VYAYVFEHRASTLSWPLWMGVP-----HGYEIEFI-----FGIPLDPS 560

  Fly   625 ----SMEVQVKNRMVRMWTNFAKYGSPTPDSEDPMLTTKWAP------------IDPTNVMNSL- 672
                :.|.....|::|.|.|||:.|.|. :..||. ..:|.|            :.|..|...|
Human   561 RNYTAEEKIFAQRLMRYWANFARTGDPN-EPRDPK-APQWPPYTAGAQQYVSLDLRPLEVRRGLR 623

  Fly   673 -------NYMDISANLAMKTNPEPERQ------RF------WDEMYQHYN 703
                   |........|..|..|.|||      |:      |...:.||:
Human   624 AQACAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKNQFDHYS 673

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	190/617 (31%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	183/587 (31%)
		AChE_tetra	645..678	CDD:400834	8/29 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.910