DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10175 and CG4757

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster

Alignment Length:	600	Identity:	191/600 - (31%)
Similarity:	273/600 - (45%)	Gaps:	130/600 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 IVATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWS-GIRDASREGQS 217
            |...|.||:|||.....|.|.  .:::|:|:||..||.|..||...:|.|||| .|.|||.:|..
  Fly    21 IEVDTELGRVRGANLTSRLGV--NFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPM 83

  Fly   218 CPH--KNMILDTFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNS-FLYGP 279
            ||.  .|| .|.   .||||.:||:|..:        :.:.||:|:||.|||...||.| :|.||
  Fly    84 CPQPWDNM-TDV---SEDCLRLNVYTKDL--------KGRRPVIVFLHPGGFYVFSGQSKYLAGP 136

  Fly   280 DYLVAEDIVLVTLNYRLGPLGFLTAG-PDAPGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGE 343
            ::.:..|.|||:||||||.||||..| .:||||.|||||||||:|::.:|..|||||:.||:.|.
  Fly   137 EHFMDRDCVLVSLNYRLGSLGFLATGSKEAPGNAGLKDQVLALRWIQQHIQRFGGDPDSVTLLGY 201

  Fly   344 SAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANL----GYVGANKTED 404
            |||:.||.|.:||..::|||||.|..|.:...|.....:..|.|.|.|..|    ..:|     :
  Fly   202 SAGSISVALHMLSPMSRGLFHRGICMSAAPYGPVKYKDNDLQLAKRQAGLLKCPQESIG-----E 261

  Fly   405 ILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWN----------QD-SQEEQFYEE 458
            :::.:||.|.:..|..                 :..:.|..||          :| .||....|.
  Fly   262 MVECMRRKPYLDYVST-----------------YNGMFEFGWNPVLNWRIVVEKDFGQERYLIES 309

  Fly   459 PFLTQHPSDMYHSQNFNSDVAYMTGYNTHE----AMLFIRRLRKNPQLLSIIENDF------GRL 513
            ||.|....| :|.      ||.:||....|    |...:|    |..:::....|:      ..|
  Fly   310 PFKTARRGD-FHK------VALITGITEFEFLSGAFFDLR----NESIVNRYNRDWEHYASIALL 363

  Fly   514 VPQDLNVTESHDRVTREIRSFYLGSKHVGIESVDE---------MIALLTDLM-------FLQGI 562
            :.|:...:.:..||.||        |::. ||:|:         |..||:|.:       |||
  Fly   364 LEQNSTQSRAASRVFRE--------KYMP-ESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQ-- 417

  Fly   563 RRTARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPGVCHGDELGYLFKFGFFNLSL---DPK 624
                   ....:.|:|.|.|.:.|.....|........|..|.|||.|||..|.....|   ||:
  Fly   418 -------LMSPHTPIYTYLFRYKGRYTFLKNPDNQQTIGPVHHDELIYLFHVGLLIPLLKREDPE 475

  Fly   625 SMEVQVKNRMVRMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDISANLAMKT---- 685
            :..:::   :.|||..||:.|.|...:::.:....|    |........|::|..||..|:
  Fly   476 NFMIEL---LTRMWIEFAQKGDPHNKNDEYLKGLNW----PLYNAQDKGYLEIGNNLTAKSGGFF 533

  Fly   686 -NPEPERQRFWDEMY 699
             |    |.:.|::::
  Fly   534 LN----RYQIWEDLF 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	189/591 (32%)
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	190/594 (32%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	85/177 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.960