DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10175 and alpha-Est6

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_524262.1	Gene:	alpha-Est6 / 40902	FlyBaseID:	FBgn0015574	Length:	568	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	190/560 - (33%)
Similarity:	285/560 - (50%)	Gaps:	52/560 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCP 219
            |...|:|.|:||......|:.  :|||:|:.:..||.|..||.|::...||:...||.:|.....
  Fly    42 VVKLSVGSVKGRRLSGIYGDE--FYSFEGIPFAKPPLGKARFVASQLADPWNSELDARQERPIPL 104

  Fly   220 HKNMILDTFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNSFLYGPDYLVA 284
            ..:.......|.||||::||:|...   :||  :|.|||||:::||.|..|......||||||::
  Fly   105 QMDRRSGKVVGSEDCLYLNVYTKHF---NES--EPPLPVMVYIYGGAFRTGGAVKSKYGPDYLMS 164

  Fly   285 EDIVLVTLNYRLGPLGFLT--AGP-DAPGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAG 346
            .|:|.|..||||..||||:  :|. |.|||.||.||:|||:||..:|..|.|||..:|:||||||
  Fly   165 RDVVYVLFNYRLCSLGFLSMPSGKLDVPGNAGLHDQLLALQWVSQHIRNFNGDPQNITLFGESAG 229

  Fly   347 ASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYVGANKTEDILDFLRR 411
            |:||..::...|||||||:||..|||.|:||..:..|.....|||.:.||.|..:...||:|||.
  Fly   230 AASVHFMMCLPQAKGLFHKAIMMSGSMLSPWVNAPDSDGIFCRLATSAGYEGPAEEVPILEFLRN 294

  Fly   412 VPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFNS 476
            |.|.||:  ....|:..|:......||.|||.|                |...|......:.::.
  Fly   295 VNAEKLI--GHDFISPRDRCFGFLNPFAPVVGG----------------LVAAPFQQLMKEAWSC 341

  Fly   477 DVAYMTGYNTHEAMLFIRRLR-KNPQLLSIIENDFGRLVPQDLNVT---ESHDRVTREIRSFYLG 537
            :|..:.|..:.|.:::....: .|..:|.:::::...::|.:|..:   |..:.....:..::.|
  Fly   342 EVPLLLGGTSFEGLVYYPFCQLDNGYMLELLKHEPAMVLPHELYQSMSVEERNTAADVLVKYHYG 406

  Fly   538 SKHVGIESVDEMIALLTDLMFLQGIRRTARNHAKFGNAPVYMYRFSFDG-SLGLYKRML---GIP 598
            .:.:...::.:::.|.:..:|..||.|...:......||.|:|||.||. .|.|.:..|   .|.
  Fly   407 PRGITKSNITQILDLFSYKLFWHGIHRVVLSRLSHAQAPTYLYRFDFDSPKLNLMRNQLCGDDIK 471

  Fly   599 RPGVCHGDELGYLF-KFGFFNLSLD-PKSMEVQVKNRMVRMWTNFAKYGSPT-PDS-EDPMLTTK 659
            | ||||.|:|||:| |.......|| |:.:.:|   |||.:.|.||:.|.|. |:: .||
  Fly   472 R-GVCHADDLGYIFHKQAQAKQPLDSPEFLTIQ---RMVGILTTFARTGDPNCPETGPDP----- 527

  Fly   660 WAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFWDEMY 699
            |.|:...:...:||   |...:...|..|.:..:.|:.:|
  Fly   528 WMPVSTKSPFKALN---IGQQVECVTQVEKDGLKVWNRLY 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	187/552 (34%)
alpha-Est6	NP_524262.1	COesterase	35..534	CDD:278561	183/525 (35%)
alpha-Est6	NP_524262.1	Aes	<133..325	CDD:223730	94/193 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26925
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.870