Protein Alignment CG10175 and Ces3a

DIOPT Version :9

• Sequence 1: NP_001287487.1
• Gene: CG10175 / 42773
• FlyBaseID: FBgn0039084
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_941074.1
• Gene: Ces3a / 382053
• MGIID: 102773
• Length: 571
• Species: Mus musculus
• Alignment Length: 651
• Identity: 183/651 - (28%)
• Similarity: 260/651 - (39%)
• Gaps: 159/651 - (24%)

  Fly   102 DMRQMAHMGSSTTETTAWKTLTSHPNSLVQLLPSRAM--RVVQEVVRSLRKEREIVATTSLGKVR 164
            :|...|..|||   ...|..      .|:.:.|:..:  :|.|..|           .|.||:||
Mouse     3 NMETTAQAGSS---VRVWMA------CLLLIFPTTVIGPKVTQPEV-----------DTPLGRVR 47

  Fly   165 GRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCPHK-------- 221
            ||....:..:| ....|.|:.:...|.|..||.|..|.:||.|:||||.....|...
Mouse    48 GRQVGVKDTDR-MVNVFLGIPFAQAPLGPLRFSAPLPPQPWEGVRDASINPPMCLQDVERMSNSR 111

  Fly   222 ---NMILDTFKGDEDCLFVNVFT-TQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNSF------L 276
               |..:..|...||||.:|::: |::...|      |.|||||:|||....||..|.      .
Mouse   112 FTLNEKMKIFPISEDCLTLNIYSPTEITAGD------KRPVMVWIHGGSLLVGSSTSHDGSALAA 170

  Fly   277 YGPDYLVAEDIVLVTLNYRLGPLGFLTAG-PDAPGNQGLKDQVLALKWVRDNIAAFGGDPNQVTI 340
            ||       |:|:||:.||||..|||:.| ...|||:|..|.|.||:||:.|||.||||||.|||
Mouse   171 YG-------DVVVVTVQYRLGIFGFLSTGDKHMPGNRGFLDVVAALRWVQGNIAPFGGDPNCVTI 228

  Fly   341 FGESAGASSVQLLLLSSQAKGLFHRAISQSG-------SALNPWSMSASSSQRAARLAANLGYVG 398
            ||.|||...|..||||..:.|||||||||||       ..||.||        .|:..||....|
Mouse   229 FGNSAGGIIVSSLLLSPMSAGLFHRAISQSGVVISKILEDLNAWS--------EAQNFANSVACG 285

  Fly   399 ANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQ 463
            :....:::..|.:.....|:           .:.|:.:       .|...||         |..|
Mouse   286 SASPAELVQCLLQKEGKDLI-----------TKKNVNI-------SYTVNDS---------FFPQ 323

  Fly   464 HPSDMYHSQNFNSDVAYMTGYNTHE----AMLFIRRLRKNPQLL--SIIENDFGRL----VPQDL 518
            .|..:..::.|.: |.|:.|...||    .:.|...|.|...|.  .::||....|    :|.::
Mouse   324 RPQKLLANKQFPT-VPYLLGVTNHEFGWLLLKFWNILDKMEHLSQEDLLENSRPLLAHMQLPPEI 387

  Fly   519 NVT---ESHDRVTREIRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRRTARNHAKFGNAPVYMY 580
            ..|   |..|..:.|..:.|...:.:|     ::..::..|:|        ..:.:....||::|
Mouse   388 MPTVIDEYLDNGSDESATRYALQELLG-----DITLVIPTLIF--------SKYLQDAGCPVFLY 439

  Fly   581 RFSF-DGSLGLYKRMLGIPRPG---VCHGDELGYLFKFGFFNLSLDPKSM---------EVQVKN 632
            .|.. ..|...:|       |.   ..|..|..::|...|..   |..|:         |.|:..
Mouse   440 EFQHTPSSFAKFK-------PAWVKADHSSENAFVFGGPFLT---DESSLLAFPEATEEEKQLSL 494

  Fly   633 RMVRMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSL-NYMDISANLAMKTNPEPERQRFWD 696
            .|:..|:.||:.|:|......|     |..      :|.| .|::|..........:..|.:||.
Mouse   495 TMMAQWSQFARTGNPNGKGLPP-----WPQ------LNQLEQYLEIGLEPRTGVKLKKGRLQFWT 548

  Fly   697 E 697
            |
Mouse   549 E 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	169/590 (29%)
Ces3a	NP_941074.1	COesterase	36..547	CDD:278561	171/605 (28%)
		Aes	75..>245	CDD:223730	78/182 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.910