DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10175 and Jhedup

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_611085.2	Gene:	Jhedup / 36779	FlyBaseID:	FBgn0034076	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	157/512 - (30%)
Similarity:	251/512 - (49%)	Gaps:	47/512 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VATTSLGKVRGRYQK-YRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSC 218
            |....:|.:||.... |:|||   :.:|.|:.:..||.|..|.:...|.:||.|:.||.....||
  Fly    22 VCLEDMGCMRGTLMPGYQSGE---FEAFMGIPFAQPPVGPLRLKNPVPNEPWEGVLDAGAAKDSC 83

  Fly   219 PHKNMILDTF--KGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNSFLYGPDY 281
            ..::.....:  .|.||||::||:..:...:|      ||||||::|||||..||.:....||:|
  Fly    84 IQRSYFAKEWGLMGVEDCLYLNVYRPKNRAED------KLPVMVYIHGGGFFSGSAHPMASGPEY 142

  Fly   282 LV-AEDIVLVTLNYRLGPLGFLTAGPD-APGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGES 344
            |: ...:|:||:||||||.|||:.|.: .|||.|.|||.|||:|::.:||.|||||.:||:.|.|
  Fly   143 LMDTNKVVMVTMNYRLGPFGFLSTGDEHMPGNFGFKDQRLALQWIQKHIATFGGDPKKVTVLGHS 207

  Fly   345 AGASSVQLLLLSSQAKGLFHRAISQSGSA-LNPWSMSASSSQRAARLAANLGYVGAN--KTEDIL 406
            ||..|..|.::|..:||||..::|.:|:. |:...:......:|.||...|....|.  .::|:.
  Fly   208 AGGISAHLHMISPNSKGLFQNSMSLTGTMFLSAMKILKDPLSQARRLGKELAIDQAESLSSQDLA 272

  Fly   407 DFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQHPSDMYHS 471
            :.||.|...||:.:..:....::..:   |..:||:|..          ..:.||.:.|.|.:.:
  Fly   273 EALRNVCPKKLLVSVDSLKVWDNMPH---LTTLPVLEAP----------SPDAFLVEDPLDAHRA 324

  Fly   472 QNFNSDVAYMTGYNTH--EAMLFIRRLRKNPQLLSIIENDFGRLVPQDLNVTESHD-RVTREIRS 533
            ...| .:.::...::.  |..|||.|...||:|.:....:|...:...||:.|... ::..||..
  Fly   325 GRIN-QMPWILSLSSRAGEGSLFIMRAFINPKLRAEFNENFLEHMALLLNLPEGTPVQMVSEILD 388

  Fly   534 FY-LGSKHVGIESVDEMIALLTDLMFLQGIRRTARNHAKFGNA---PVYMYRFSFDGSLGLYKRM 594
            .| .....:..:::.::..:..|..|...|..|..::..:.|.   |:::|.|.|.|...:.|..
  Fly   389 AYDFKGDSLNNDTMLKLAEISGDFNFYYPIYETISSYVTYANLEENPLFIYIFEFAGLNSITKFF 453

  Fly   595 LGIPRP---GVCHGDELGYLFKFGFFNLSLD--PK-SMEVQVKNRMVRMWTNFAKYG 645
            .|....   |..|.|:..:..:   ..:|.|  || |.:.:|..||..:.|:|||.|
  Fly   454 AGTTDDYGLGAVHMDDGLHTIR---IPVSFDDFPKDSEDAKVIQRMSSLMTDFAKTG 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	156/510 (31%)
Jhedup	NP_611085.2	COesterase	31..508	CDD:278561	155/503 (31%)
Jhedup	NP_611085.2	Aes	<106..>210	CDD:223730	55/109 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.960