DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10175 and CG3841

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001188759.1	Gene:	CG3841 / 34278	FlyBaseID:	FBgn0032131	Length:	564	Species:	Drosophila melanogaster

Alignment Length:	568	Identity:	174/568 - (30%)
Similarity:	264/568 - (46%)	Gaps:	69/568 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSG-IRDASREGQSC 218
            |...|||:::|  ...:|......|:|:|:||...|.|..||....||..|.. :.:|:.:...|
  Fly    30 VVELSLGRIQG--DTMQSFGNKTIYAFRGIRYAQSPVGQLRFANPVPETSWGDEVFNATSDSLVC 92

  Fly   219 PHKNMILDTFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSG-NSFLYGPDYL 282
            |...::   ....||||.:||||...        :.|.||||::|||....||| :|:..||.||
  Fly    93 PQPGVV---SLMSEDCLKINVFTKSF--------EDKFPVMVYIHGGANVLGSGHSSYEAGPQYL 146

  Fly   283 VAEDIVLVTLNYRLGPLGFL-TAGPDAPGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAG 346
            :.:|:|.|..|||||.|||| |...:..||.|..|||:||:||||:|:.|||||..|||.|.|||
  Fly   147 LDQDVVFVAFNYRLGALGFLSTNSSETKGNFGFLDQVMALEWVRDHISHFGGDPELVTIIGISAG 211

  Fly   347 ASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYVGANKTEDILDFLRR 411
            :.:|.|.|.|..:.|||||||..||||.|.:.:......|  :||..||....:.| |:::.||.
  Fly   212 SMAVSLHLASPLSAGLFHRAILMSGSATNHFDIDNLFWTR--KLARELGCPMYDPT-DVVECLRN 273

  Fly   412 VPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFN- 475
            ....::||......|.:            :|...||.:      .:..||..||:::....|||
  Fly   274 ETWTRIVEVCKAWETYQ------------LVNMKWNYE------IDGHFLHNHPTELIKEGNFNK 320

  Fly   476 -----SDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQDLNVTESHDRVTREIRSFY 535
                 |..|....||.:..:       :|..||....::|....| :|.:.....::..:::.||
  Fly   321 VPLLISFTANEFDYNANVHL-------ENQHLLHDFASNFVDYAP-ELFLYRHDAQIGEKLKDFY 377

  Fly   536 LG--SKHVGIESVDEMIALLTDLMFLQGIRRTARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIP 598
            ||  :..:..|:::....:.:|.....|:.|..:..:.|  .|||..|..:.|...|...:.|..
  Fly   378 LGDNTTEINSENIENFGQIFSDAYIGHGVHRLVQLASHF--TPVYYTRMDYVGDQSLSAPLNGEN 440

  Fly   599 RP-GVCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRMVRMWTNFAKYGSPTPDSEDPMLTTKWAP 662
            :| ||.|.|:|.|:....::...:.....:|.:..|:...:|:|||.|:|...      |..|.|
  Fly   441 KPVGVGHADDLHYVLPGYWYGPLMAANDSDVFMMERLTSWFTHFAKTGTPLNS------TDIWPP 499

  Fly   663 IDPTNVMNSLNYMDISANLAMKTNPEPERQRFWDEMY---QHYNGAAM 707
            .:.|.:....|.:.........:|    |...||:::   ....|||:
  Fly   500 CNSTVLKMLYNGVVTQVGSPGYSN----RYAVWDKLFPTAAQGGGAAL 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	168/549 (31%)
CG3841	NP_001188759.1	COesterase	27..528	CDD:278561	169/551 (31%)
CG3841	NP_001188759.1	Aes	<116..>235	CDD:223730	65/118 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I1867
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40835at6656
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.870