DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10175 and Ces2i

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	XP_008758816.2	Gene:	Ces2i / 292152	RGDID:	1565045	Length:	558	Species:	Rattus norvegicus

Alignment Length:	561	Identity:	169/561 - (30%)
Similarity:	262/561 - (46%)	Gaps:	76/561 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCP 219
            :..|..|:|||.:...:. .:.|.::|.|:.:..||.|...|...|..:||||:||.:.:...|.
  Rat    33 IRNTQTGQVRGSFVHVKD-TKSGVHTFLGIPFAKPPVGPLHFAPPEDPEPWSGVRDGTSQPDMCL 96

  Fly   220 HKNMILDTFKGD-----------EDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGN 273
            ..:::.:.|..:           ||||::|::|..     .:.|...||||||:||||...||.
  Rat    97 QTDIMKEDFIKEMKLTMHPTPMSEDCLYLNIYTPA-----HAREGSNLPVMVWIHGGGLVLGSA- 155

  Fly   274 SFLYGPDYLVAEDIVLVTLNYRLGPLGFLTAGPD-APGNQGLKDQVLALKWVRDNIAAFGGDPNQ 337
            |..........|:||:|.:.||||.|||.:.|.: |.||.|..|||.||.||:.|||.|||:..:
  Rat   156 SMNVASTLAATEEIVIVAIQYRLGILGFFSTGDEHARGNWGYLDQVAALCWVQQNIAYFGGNHGK 220

  Fly   338 VTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYVGANKT 402
            |||||.|||.:||...::|..:|||||.||.|||.||.| .:.:.:|:...:..|||....|:.:
  Rat   221 VTIFGVSAGGTSVSSHVVSPMSKGLFHGAIMQSGVALLP-DLISDTSEVVYKTVANLSGCEASDS 284

  Fly   403 EDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVP-VVEGYWNQDSQEEQFYEEPFLTQHPS 466
            |.::..||.....:::..            |.....:| ||:|              .||.:||.
  Rat   285 EALIRCLRAKSKQEILAI------------NQVFKMIPGVVDG--------------KFLPKHPQ 323

  Fly   467 DMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQDLNVTESHDRVTRE- 530
            ::..|.:|: .|..:.|.||.|..|.:........::..|..|   .:|..|..|.:...:..|
  Rat   324 ELLASGDFH-PVPSIIGVNTDECGLGVPMFMGLDHIIKKITRD---TLPTVLKSTAAQMMLPPEC 384

  Fly   531 ---IRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRRTARNHAKFGNAPVYMYRFSFDGSLGLYK 592
               |...|:|.........::...:|.|.||:......|  |.:...||||.|.|....|  ..|
  Rat   385 IDLIMEEYMGDTEDPETLQEQFKEMLGDFMFVIPALEVA--HFQRSQAPVYFYEFQHLPS--FIK 445

  Fly   593 RMLGIPRPG---VCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRMVRMWTNFAKYGSPTPDSEDP 654
            ::    ||.   ..|||::.::|...|:.::.|....|..:|.|:::.|.|||:.|:  |:|||
  Rat   446 QV----RPSHVKADHGDDILFVFSSYFWGMNFDITEEEELLKRRVMKYWANFARNGN--PNSED- 503

  Fly   655 MLTTKWAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFW 695
              ...|..:|     ::..|:.::...|:....:..|.:||
  Rat   504 --LPYWPVLD-----HNEQYLQLNTQPAVGRALKARRLQFW 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	167/557 (30%)
Ces2i	XP_008758816.2	COesterase	30..537	CDD:395084	167/559 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910