Protein Alignment CG10175 and CES4A

DIOPT Version :9

• Sequence 1: NP_001287487.1
• Gene: CG10175 / 42773
• FlyBaseID: FBgn0039084
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 672
• Identity: 194/672 - (28%)
• Similarity: 288/672 - (42%)
• Gaps: 164/672 - (24%)

  Fly   129 LVQLLPSR----AMR-----------VVQEVVRSLRKEREIVATTSLGKVRGRYQKYRSGERGGY 178
            |..|||:.    :||           :.|..:.:|..:|..| .|..|.::|   |.....:...
Human    11 LPSLLPTAGAGWSMRWILCWSLTLCLMAQTALGALHTKRPQV-VTKYGTLQG---KQMHVGKTPI 71

  Fly   179 YSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDA-------------------------------- 211
            ..|.|:.:..||.|..||...||.:||.|||||
Human    72 QVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPGWSLALSPGWSAVARSRLTATSASRVQ 136

  Fly   212 --------SREGQSCPHK------NMILDT------FKGDEDCLFVNVFT-TQMPKDDESAEQPK 255
                    |..|..|..:      :|.:.|      .:..||||::||:. .:.|.|      |:
Human   137 ASLLPQPLSIWGYRCLQESWGQLASMYVSTRERYKWLRFSEDCLYLNVYAPARAPGD------PQ 195

  Fly   256 LPVMVWLHGGGFSFGSGNSFLYGPDYLVAEDIVLVTLNYRLGPLGFL-----TAGPDAPGNQGLK 315
            ||||||..||.|..|:.:|: .|.|....|.:|||.|.:|||..|||     |....|.||.||.
Human   196 LPVMVWFPGGAFIVGAASSY-EGSDLAAREKVVLVFLQHRLGIFGFLRWRGRTDDSHARGNWGLL 259

  Fly   316 DQVLALKWVRDNIAAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMS 380
            ||:.||:||::|||||||||..||:||:||||.|:..|::|..|.|||||||||||:||....::
Human   260 DQMAALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPLASGLFHRAISQSGTALFRLFIT 324

  Fly   381 ASSSQRAARLAANLGYVGANKTEDILDFLRRVPAMKLVEAAPTT--ITAEDQRN--NIGLPFVPV 441
             |:..:.|:..|:|.....|.|:.:::.||.:...|::..:...  :....||:  .|.....||
Human   325 -SNPLKVAKKVAHLAGCNHNSTQILVNCLRALSGTKVMRVSNKMRFLQLNFQRDPEEIIWSMSPV 388

  Fly   442 VEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHE---AMLFIRRLRKNPQ-- 501
            |:|....|        :|.:..       :|...|.|.|:.|.|..|   .:.:|.:...|.|
Human   389 VDGVVIPD--------DPLVLL-------TQGKVSSVPYLLGVNNLEFNWLLPYIMKFPLNRQAM 438

  Fly   502 --------------LLSIIENDFGRLVPQDLNVTESHD-RVTREIRSFYLGSKHVGIESVDEMIA 551
                          ||:|.:.....:|.:.|:....|| ::.|                 :.|:.
Human   439 RKETITKMLWSTRTLLNITKEQVPLVVEEYLDNVNEHDWKMLR-----------------NRMMD 486

  Fly   552 LLTDLMFLQGIRRTARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPR-PGVCHGDELGYLFKFG 615
            ::.|..|:....:||..|...| .|||:|.|....     :.::..|| .|..||||:.:||...
Human   487 IVQDATFVYATLQTAHYHRDAG-LPVYLYEFEHHA-----RGIIVKPRTDGADHGDEMYFLFGGP 545

  Fly   616 F-FNLSL-DPKSMEVQVKNRMVRMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDIS 678
            | ..||: ..|::.:|    |::.|.|||:.|:|. |...|.    |...   |.......:|.:
Human   546 FATGLSMGKEKALSLQ----MMKYWANFARTGNPN-DGNLPC----WPRY---NKDEKYLQLDFT 598

  Fly   679 ANLAMKTNPEPERQRFWDEMYQ 700
            ..:.||.  :.::..||..:||
Human   599 TRVGMKL--KEKKMAFWMSLYQ 618

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	180/622 (29%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	182/630 (29%)
		Aes	<184..>291	CDD:223730	55/113 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860