DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10175 and Ces2a

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	581	Identity:	174/581 - (29%)
Similarity:	263/581 - (45%)	Gaps:	116/581 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCP 219
            :..|..|:|||.:...:. .:.|.::|.|:.:..||.|..||...|..:||||:|||:.:...|.
  Rat    33 IRNTHTGQVRGSFVHVKD-TKSGIHTFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCL 96

  Fly   220 HKN-MILDTFKG----------DEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGN 273
            ..: |.||..|.          .||||::|::|..     .:.|...||||||:||||...||.:
  Rat    97 QTDIMNLDGIKEMKLTVHPTPMSEDCLYLNIYTPA-----HAREGSNLPVMVWIHGGGLVLGSAS 156

  Fly   274 SFLYGPDYLVA-EDIVLVTLNYRLGPLGFLTAG-PDAPGNQGLKDQVLALKWVRDNIAAFGGDPN 336
              :.....|.| |:||:|::.||||.|||.:.| .:|.||.|..|||.||:||:.|||.|||:..
  Rat   157 --MNDASTLAATEEIVIVSIQYRLGVLGFFSTGDQNARGNWGYLDQVAALRWVQQNIAYFGGNHG 219

  Fly   337 QVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYVGANK 401
            :|||||.|||.:||...::|..:|||||.||.|||.||.| .:.:..|:...:..|||....|..
  Rat   220 KVTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGVALLP-DLISDKSEVVYKTVANLSGCEAPD 283

  Fly   402 TEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVP-VVEGYWNQDSQEEQFYEEPFLTQHP 465
            :|.::..||.....:::..            |.....:| ||:|              .||.:||
  Rat   284 SEALIRCLRAKSKQEILAI------------NQVFKMIPGVVDG--------------KFLPKHP 322

  Fly   466 SDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQDLNVTESHDRVTRE 530
            .::..|.:|: .|..:.|.||.|.                     |..:|..|.:.....::|||
  Rat   323 QELLASGDFH-PVPSIIGINTDEC---------------------GWGIPVFLGLDHIIKKITRE 365

  Fly   531 ----------------------IRSFYLGSKHVGIESVDEMIA-LLTDLMFLQGIRRTARNHAKF 572
                                  |...|:|... ..|::.|... :|.|.||:....:.|  |.:.
  Rat   366 TLPTVLKSTAAQMMLPPECIDLIMEEYMGDTE-NPETLQEQFRHMLGDFMFVIPALQVA--HFQR 427

  Fly   573 GNAPVYMYRFSFDGSLGLYKRMLGIPRPG---VCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRM 634
            ..||||.|.|....|  ..|::    ||.   ..|||::.::|....:.::.|....|..:|.|:
  Rat   428 SQAPVYFYEFQHLPS--FIKQV----RPSHVKADHGDDILFVFGSYLWGMTFDLTEEEELLKRRV 486

  Fly   635 VRMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFW 695
            ::.|.|||:.|:  |:.||   ...|..:|     :...|:.::...|:....:..|.:||
  Rat   487 MKYWANFARTGN--PNGED---LPHWPVLD-----HDEQYLQLNTQPAVGRALKARRLQFW 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	172/577 (30%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	172/579 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010