DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10175 and Nlgn3

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_766520.2	Gene:	Nlgn3 / 245537	MGIID:	2444609	Length:	825	Species:	Mus musculus

Alignment Length:	672	Identity:	197/672 - (29%)
Similarity:	294/672 - (43%)	Gaps:	164/672 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   132 LLPSRAMRVVQEVVRS-----------LRKEREIVA---TTSLGKVRGRYQKYRSGERGGYYSFK 182
            |.||.::.....|.||           ||...:..|   .|..||:||......|...|....:.
Mouse     3 LQPSLSLSPTPTVGRSLCLTLGFLSLVLRASTQAPAPTVNTHFGKLRGARVPLPSEILGPVDQYL 67

  Fly   183 GMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCPHK----------------NM-ILDTF-- 228
            |:.|.|||.|.:||...||...|||||:|:.....||..                |: |:.|:
Mouse    68 GVPYAAPPIGEKRFLPPEPPPSWSGIRNATHFPPVCPQNIHTAVPEVMLPVWFTANLDIVATYIQ 132

  Fly   229 KGDEDCLFVNVFTTQMPKDDESAEQPK--------------------LPVMVWLHGGGFSFGSGN 273
            :.:||||::||:   :|.:|.|..:.:                    .||||::|||.:..|:||
Mouse   133 EPNEDCLYLNVY---VPTEDGSGAKKQGEDLADNDGDEDEDIRDSGAKPVMVYIHGGSYMEGTGN 194

  Fly   274 ----SFL--YGPDYLVAEDIVLVTLNYRLGPLGFLTAGPD-APGNQGLKDQVLALKWVRDNIAAF 331
                |.|  ||       :::::|||||:|.||||:.|.. |.||.||.||:.||:||.:|||.|
Mouse   195 MIDGSVLASYG-------NVIVITLNYRVGVLGFLSTGDQAAKGNYGLLDQIQALRWVSENIAFF 252

  Fly   332 GGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGY 396
            ||||.::|:||...|||.|.||.||..::|||.|||.||||||:.|:::....:..:.||..
Mouse   253 GGDPRRITVFGSGIGASCVSLLTLSHHSEGLFQRAIIQSGSALSSWAVNYQPVKYTSLLADK--- 314

  Fly   397 VGAN--KTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEP 459
            ||.|  .|.|::|.||:..|.:|||       .:.|.....:.|.||::|....|..|....:..
Mouse   315 VGCNVLDTVDMVDCLRQKSAKELVE-------QDIQPARYHVAFGPVIDGDVIPDDPEILMEQGE 372

  Fly   460 FLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQ-----------LLSIIENDFGRL 513
            ||             |.|:  |.|.|..|.:.|:..: .:|:           :.:.::|.:|
Mouse   373 FL-------------NYDI--MLGVNQGEGLKFVEGV-VDPEDGVSGTDFDYSVSNFVDNLYG-- 419

  Fly   514 VPQDLNVTESHDRVTREIRSFYLGSKHVGIESVDE---------MIALLTDLMFLQGIRRTARNH 569
                  ..|..|.:...|:..|       .:..|.         ::||.||..:::....||..|
Mouse   420 ------YPEGKDTLRETIKFMY-------TDWADRDNPETRRKTLVALFTDHQWVEPSVVTADLH 471

  Fly   570 AKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPG---VCHGDELGYLFKFGFFN-LSLDP---KSME 627
            |::| :|.|.|.|        |.....:.:|.   ..||||:.|:|...... ..|.|   ...:
Mouse   472 ARYG-SPTYFYAF--------YHHCQSLMKPAWSDAAHGDEVPYVFGVPMVGPTDLFPCNFSKND 527

  Fly   628 VQVKNRMVRMWTNFAKYGSPT-PDSED-PMLTTK--------WAPIDPTNVMNSLNYMDISANLA 682
            |.:...::..||||||.|.|. |..:| ..:.||        |:..:|.:.:    |:.|.....
Mouse   528 VMLSAVVMTYWTNFAKTGDPNKPVPQDTKFIHTKANRFEEVAWSKYNPRDQL----YLHIGLKPR 588

  Fly   683 MKTNPEPERQRFWDEMYQH-YN 703
            ::.:....:..||..:..| ||
Mouse   589 VRDHYRATKVAFWKHLVPHLYN 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	183/622 (29%)
Nlgn3	NP_766520.2	COesterase	39..601	CDD:365897	183/625 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	151..172		1/20 (5%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	622..668
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810