DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10175 and Cel

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_058693.2	Gene:	Cel / 24254	RGDID:	2331	Length:	612	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	175/545 - (32%)
Similarity:	260/545 - (47%)	Gaps:	88/545 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 FKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCPHKNMILDTFKGDEDCLFVNVFTTQMP 245
            |||:    |...|:.....:....|.|...|:...:.|....:..|...|.||||::|::..|..
  Rat    51 FKGI----PFATAKTLENPQRHPGWQGTLKATDFKKRCLQATITQDDTYGQEDCLYLNIWVPQGR 111

  Fly   246 KDDESAEQPKLPVMVWLHGGGFSFGSG------NSFLY-GPDYLVAEDIVLVTLNYRLGPLGFLT 303
            |.    ....||||||::||.|..|||      .::|| |.:.....::::||.|||:||||||:
  Rat   112 KQ----VSHDLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEEIATRGNVIVVTFNYRVGPLGFLS 172

  Fly   304 AGPDA--PGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRA 366
            .| ||  |||.||:||.:|:.||:.|||||||||:.:|||||||||:||.|..||...|||..||
  Rat   173 TG-DANLPGNFGLRDQHMAIAWVKRNIAAFGGDPDNITIFGESAGAASVSLQTLSPYNKGLIRRA 236

  Fly   367 ISQSGSALNPWSMSASSSQRAARLAANLGYVGANKTEDILDFLRRVPAMKLVEAAPTTIT----A 427
            |||||.||:||::..:....|..:|..:|.    .|||.   .:....:|:.:....|:.    .
  Rat   237 ISQSGVALSPWAIQENPLFWAKTIAKKVGC----PTEDT---AKMAGCLKITDPRALTLAYRLPL 294

  Fly   428 EDQRNNI--GLPFVPVVEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAM 490
            :.|...|  .|.|:|||:|              .|:...|.::|.:.   :|:.|:.|.|..:..
  Rat   295 KSQEYPIVHYLAFIPVVDG--------------DFIPDDPINLYDNA---ADIDYLAGINDMDGH 342

  Fly   491 LF----IRRLRKNPQLLSIIENDFGRLVPQDLNVTESHDRVTREIR----SFYLGSKHVGIESVD 547
            ||    :..:.|..|  .:.|.||.|||        |...|.:.::    :|.:.::....:...
  Rat   343 LFATVDVPAIDKAKQ--DVTEEDFYRLV--------SGHTVAKGLKGTQATFDIYTESWAQDPSQ 397

  Fly   548 E-----MIALLTDLMFL---QGIRRTARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPGVCH 604
            |     ::|..||::||   :......|.|||  :|..|.|.||....:.:|.:.:|..     |
  Rat   398 ENMKKTVVAFETDILFLIPTEMALAQHRAHAK--SAKTYSYLFSHPSRMPIYPKWMGAD-----H 455

  Fly   605 GDELGYLFKFGFFNLSLDPKSMEVQVKNRMVRMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVM 669
            .|:|.|:|...|.. .|..::.:..|...|:..||||||.|.|...:..  :.|.|.|....|.
  Rat   456 ADDLQYVFGKPFAT-PLGYRAQDRTVSKAMIAYWTNFAKSGDPNMGNSP--VPTHWYPYTTENG- 516

  Fly   670 NSLNYMDISANLAMKTNPEPERQRF 694
               ||:||:..:...:..|..|::|
  Rat   517 ---NYLDINKKITSTSMKEHLREKF 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	175/545 (32%)
Cel	NP_058693.2	COesterase	26..542	CDD:278561	175/545 (32%)
		Aes	<118..>247	CDD:223730	74/129 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..612
		4 X 11 AA tandem repeats, O-glycosylated region	556..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720