Protein Alignment CG10175 and CES5A

DIOPT Version :9

• Sequence 1: NP_001287487.1
• Gene: CG10175 / 42773
• FlyBaseID: FBgn0039084
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_001177087.1
• Gene: CES5A / 221223
• HGNCID: 26459
• Length: 604
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 173/570 - (30%)
• Similarity: 266/570 - (46%)
• Gaps: 97/570 - (17%)

  Fly   158 TSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCPHKN 222
            |.||.::|: |....|.......|.|:.:.|||.|:.||...:|..||..:|:|:.....|...:
Human    64 TRLGWIQGK-QVTVLGSPVPVNVFLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLCLQNS 127

  Fly   223 --MILD---------TFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNSFL 276
              ::||         .|...||||::|::.   |...::..  ||||:||..||.|..||.:.|
Human   128 EWLLLDQHMLKVHYPKFGVSEDCLYLNIYA---PAHADTGS--KLPVLVWFPGGAFKTGSASIF- 186

  Fly   277 YGPDYLVAEDIVLVTLNYRLGPLGFLTA-GPDAPGNQGLKDQVLALKWVRDNIAAFGGDPNQVTI 340
            .|......||:::|.:.||||..||.|. ...||||...||||.||.||:.||..|||||:.|||
Human   187 DGSALAAYEDVLVVVVQYRLGIFGFFTTWDQHAPGNWAFKDQVAALSWVQKNIEFFGGDPSSVTI 251

  Fly   341 FGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYVG--ANKTE 403
            |||||||.||..|:||..||||||:||.:||.|:.|: :.|...:::..|.....:.|  |:.:|
Human   252 FGESAGAISVSSLILSPMAKGLFHKAIMESGVAIIPY-LEAHDYEKSEDLQVVAHFCGNNASDSE 315

  Fly   404 DILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQHPSDM 468
            .:|..||..|:.:|:..:..|.:           |..||:|              .|....|.|:
Human   316 ALLRCLRTKPSKELLTLSQKTKS-----------FTRVVDG--------------AFFPNEPLDL 355

  Fly   469 YHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLS---------IIENDFGRLVPQDLNVTESH 524
            ...:.|.: :..:.|.|.||.. |:..:::.|::||         :|:|.. .:.||.|::
Human   356 LSQKAFKA-IPSIIGVNNHECG-FLLPMKEAPEILSGSNKSLALHLIQNIL-HIPPQYLHL---- 413

  Fly   525 DRVTREIRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRRTARNHAKFGNAPVYMYRF-----SF 584
                  :.:.|...||...|..|.::.||.|:.|:.....|||.|...| ||||.|.|     .|
Human   414 ------VANEYFHDKHSLTEIRDSLLDLLGDVFFVVPALITARYHRDAG-APVYFYEFRHRPQCF 471

  Fly   585 DGSLGLYKRMLGIPRPGVCHGDELGYLFKFGFFN---LSLDPKSMEVQVKNR-MVRMWTNFAKYG 645
            :.:...:.:        ..|.||:.::|...|..   :..:..:.|.::.:| |::.|..||:.|
Human   472 EDTKPAFVK--------ADHADEVRFVFGGAFLKGDIVMFEGATEEEKLLSRKMMKYWATFARTG 528

  Fly   646 SPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFW 695
            :  |:..|..|   |...:.|.     .|:.:..|:::....:..|..||
Human   529 N--PNGNDLSL---WPAYNLTE-----QYLQLDLNMSLGQRLKEPRVDFW 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	171/568 (30%)
CES5A	NP_001177087.1	COesterase	56..568	CDD:278561	171/568 (30%)
		Aes	<155..>258	CDD:223730	51/108 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860