Protein Alignment CG10175 and Nlgn2

DIOPT Version :9

• Sequence 1: NP_001287487.1
• Gene: CG10175 / 42773
• FlyBaseID: FBgn0039084
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_001351066.1
• Gene: Nlgn2 / 216856
• MGIID: 2681835
• Length: 836
• Species: Mus musculus
• Alignment Length: 616
• Identity: 191/616 - (31%)
• Similarity: 280/616 - (45%)
• Gaps: 104/616 - (16%)

  Fly   147 SLRKEREIVATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDA 211
            ||.:||..|..|:.|:|||..::..:...|....|.|:.|..||.|||||:..|....|.|:|:|
Mouse    35 SLGEERFPVVNTAYGRVRGVRRELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNA 99

  Fly   212 SREGQSCPHK------NMILDTFKGD-------------EDCLFVNVF--------------TTQ 243
            :....:||..      .::|..:..|             ||||::|::              .|.
Mouse   100 TTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKRDEATL 164

  Fly   244 MPKDDESAEQPKLPVMVWLHGGGFSFGSGNSF------LYGPDYLVAEDIVLVTLNYRLGPLGFL 302
            .|.|.:..:..|.|||::||||.:..|:||.|      .||       ::::||||||||.||||
Mouse   165 NPPDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYG-------NVIVVTLNYRLGVLGFL 222

  Fly   303 TAGPD-APGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRA 366
            :.|.. |.||.||.||:.||:|:.:|||.|||||.::||||..||||.|.||:||..::|||.:|
Mouse   223 STGDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKA 287

  Fly   367 ISQSGSALNPWSMSASSSQRAARLAANLGYVGANKTEDILDFLRRVPAMKLVEAAPTTITAEDQR 431
            |:|||:|::.||::....:....|||.:|....:.||.: :.|||..:.:||:       .:.|.
Mouse   288 IAQSGTAISSWSVNYQPLKYTRLLAAKVGCDREDSTEAV-ECLRRKSSRELVD-------QDVQP 344

  Fly   432 NNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRL 496
            ....:.|.|||:|....|..|....:..||             |.|:  :.|.|..|.:.|:...
Mouse   345 ARYHIAFGPVVDGDVVPDDPEILMQQGEFL-------------NYDM--LIGVNQGEGLKFVEDS 394

  Fly   497 RKNPQLLSIIENDF--GRLVPQDLNVTESHDRVTREIRSFYL--GSKHVGIESVDEMIALLTDLM 557
            .::...:|....||  ...|.......|..|.:...|:..|.  ..:..|......::||.||..
Mouse   395 AESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLALFTDHQ 459

  Fly   558 FLQGIRRTARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRP---GVCHGDELGYLFKFGFFNL 619
            ::.....||:.||.: .:|||.|.|        |.......||   ...|||||.|:|.......
Mouse   460 WVAPAVATAKLHADY-QSPVYFYTF--------YHHCQAEGRPEWADAAHGDELPYVFGVPMVGA 515

  Fly   620 S-LDP---KSMEVQVKNRMVRMWTNFAKYGSPT-PDSEDPMLTTKWAPIDPTN----VMNSLN-- 673
            : |.|   ...:|.:...::..||||||.|.|. |..:|    ||:....|..    |.:..|
Mouse   516 TDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQD----TKFIHTKPNRFEEVVWSKFNSK 576

  Fly   674 ---YMDISANLAMKTNPEPERQRFWDEMYQH 701
               |:.|.....::.|....:..||.|:..|
Mouse   577 EKQYLHIGLKPRVRDNYRANKVAFWLELVPH 607

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	182/598 (30%)
Nlgn2	NP_001351066.1	COesterase	42..601	CDD:306613	183/601 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661
		Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810