DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10175 and cest-28

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_504691.2	Gene:	cest-28 / 187305	WormBaseID:	WBGene00019654	Length:	548	Species:	Caenorhabditis elegans

Alignment Length:	581	Identity:	166/581 - (28%)
Similarity:	271/581 - (46%)	Gaps:	99/581 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 RKEREIVATTSLGKVRGRYQKYRSGER--GGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDA 211
            |::.......:.|.::|..  ||.|::  .||.   |:.:..|..   ||:..||...|..:||.
Worm    10 REKHSEKLNATCGPIQGNV--YRIGDKTVDGYL---GIPFAKPLV---RFKKPEPAGTWEEVRDC 66

  Fly   212 SREGQSCPHK-------NMILDTFKGDEDCLFVNVFTTQMPKDDESAEQPKL-PVMVWLHGGGFS 268
            ::.|..||..       |...|....:.:||.:|||:    |..:|....|. ||||::||||:.
Worm    67 TKYGPRCPQSGPFAEAINFQKDDIPDEANCLTLNVFS----KISDSKNFNKTRPVMVYIHGGGYE 127

  Fly   269 FGSGNSFLYGPDYLVA-----EDIVLVTLNYRLGPLGFLTAGPD-APGNQGLKDQVLALKWVRDN 327
            ..:...:.   ||.||     :|:|:||||||:|.|||.|.|.. .|||..|.|..|.|.|::.:
Worm   128 CSASRDYC---DYSVAGTLPLKDVVVVTLNYRVGILGFFTTGDTVCPGNFALWDLTLGLNWIQKH 189

  Fly   328 IAAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAA--RL 390
            |.:|||||..:||||:||||:.|.||.||..::.||:|.|..||.||..:::..::||...  ..
Worm   190 IESFGGDPGNITIFGQSAGAACVDLLALSPHSRDLFNRVIVMSGGALCEYAVRTANSQAKVCYEF 254

  Fly   391 AANLGYVGANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQF 455
            |.:|||.|.| ::.:.::::..|..::           ::.|...:|...::.  |..:..::.|
Worm   255 ARHLGYDGTN-SQTLFNWMKSKPLEEI-----------EKMNGFQVPASGILA--WTPNLDDDFF 305

  Fly   456 ---YEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNP----QLLSIIENDFGRL 513
               .:|..:.....|:            |.|:..||. ||...|.|:|    :.|.:..|::.:
Worm   306 PKSLDELRIGAPKKDI------------MMGFAEHEG-LFFEFLIKDPTPPLEALKLYVNEYYK- 356

  Fly   514 VPQDLNVTESHDRVTR-EIRSFYLGSKHVGIESVDE------MIALLTDLMFLQGIRRTARNHAK 571
              :|   |..|...|| :|..||  |::|  |..||      :|..:.|.:|..|:...|:|..|
Worm   357 --KD---TGDHFEATRNKIIEFY--SRNV--EDTDEKSTKERLIDFVGDALFTAGVFDNAKNCLK 412

  Fly   572 FGNAPVYMYRFSF--DGSLGLYKRMLGIPRPGVCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRM 634
            .|| .|::|.|.:  ....|..:..:....|  .|..:|.|:...|.:: ...|...|.::..:|
Worm   413 HGN-NVWLYIFDYCNPSGFGNQEEFMTFVAP--THCTDLRYVLGEGLYS-DFQPTEEEHKMIEKM 473

  Fly   635 VRMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDIS-ANLAMKTNPEPERQRF 694
            ..:::||||||:|....     :::|   :...:.|...:..|| ....|:.:..|:|.:|
Worm   474 TTIYSNFAKYGNPNEHG-----SSEW---EKFTLDNPRRHFQISYPRGKMRNDYHPDRMKF 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	165/573 (29%)
cest-28	NP_504691.2	COesterase	17..516	CDD:278561	161/562 (29%)
cest-28	NP_504691.2	Aes	<112..>222	CDD:223730	54/112 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I1491
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71115
Inparanoid	1	1.050	221	1.000	Inparanoid score	I2278
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.760