DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10175 and cest-31

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_504692.3	Gene:	cest-31 / 187304	WormBaseID:	WBGene00019653	Length:	541	Species:	Caenorhabditis elegans

Alignment Length:	592	Identity:	168/592 - (28%)
Similarity:	266/592 - (44%)	Gaps:	117/592 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCP 219
            |..::.|.|:|...::.:.|..||.   |:.|..||.|..||:.......|:..||.::.|..||
Worm    16 VLNSTCGPVQGNLYRHGNEEVHGYL---GIPYAQPPIGILRFKKPVSADVWTETRDCTKYGPRCP 77

  Fly   220 HKNMILDTFK-------GDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNSFLY 277
            ...|:.:..:       .:.:||.:|||..|.    |..:..|.|||:::|||||...:...:.
Worm    78 PSGMLYENLQLPNTDIPDEANCLSLNVFCPQW----EIKQSAKHPVMIFIHGGGFELSASKDYC- 137

  Fly   278 GPDY-----LVAEDIVLVTLNYRLGPLGFLTAGPDA-PGNQGLKDQVLALKWVRDNIAAFGGDPN 336
              ||     |..:|:::||:|||:|.|||||.|.|: .||.||.|..||||||..:|::|||||.
Worm   138 --DYSLSGTLPLKDVIVVTVNYRVGALGFLTTGDDSCRGNFGLWDLTLALKWVSTHISSFGGDPK 200

  Fly   337 QVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQR--AARLAANLGYVGA 399
            .||:||:||||....||.||..::.|||:.|..||||..|:::....:|.  ....|.:.|:.|:
Worm   201 NVTLFGQSAGAVCADLLNLSPYSRDLFHKLIIMSGSAHVPFAIRTEENQALVCMEYARSRGFSGS 265

  Fly   400 NKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQH 464
            ...| :|:|...:|..||:|......|.     :|.|.|.|.::|         .|:.:|.
Worm   266 GSAE-LLEFFENLPIEKLLEKTGLKHTV-----SIDLSFAPNLDG---------DFFPKPL---- 311

  Fly   465 PSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIEND-----------------FGR 512
                                   |.:.  |..||.|.::.::|::                 |.|
Worm   312 -----------------------EELR--RETRKKPVIVGMMEDEGLITAFADGDFTTCEENFKR 351

  Fly   513 LVPQDL--NVTESHDRVTREIRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRRTARNHAKFGNA 575
            .|..:.  :|.|:.:.|.:.|.:||  :.:.......:::..:...::..|:..:|.:.|:.||.
Worm   352 RVESEYRGDVVENPENVQKNIMNFY--TNYCDESEERKLVDYIGHSVYNAGVLLSAESLARAGNC 414

  Fly   576 PVYMYRFSF-----DGSLGLYKRMLGIPRPGVCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRMV 635
             ||.|.|.|     .|.:|..     :|..|..|..||.|:...|.:: ..|....::::...|.
Worm   415 -VYFYVFDFWNPDGFGPVGSI-----VPFKGAAHCSELRYIIGEGVYS-KFDANEKDLKMMEYMT 472

  Fly   636 RMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFWDEM-- 698
            .|:|||||||:|....     .|.|    .|....|.::...|.:..||.:.:..|.:|..::
Worm   473 TMFTNFAKYGNPNIPG-----VTNW----ETYTEGSRHFHIDSTDSEMKDSFQENRCQFLKQIQE 528

  Fly   699 ----YQH 701
                |||
Worm   529 QSKRYQH 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	163/576 (28%)
cest-31	NP_504692.3	COesterase	16..522	CDD:278561	164/577 (28%)
cest-31	NP_504692.3	Aes	<112..>211	CDD:223730	49/101 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I1491
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H71115
Inparanoid	1	1.050	221	1.000	Inparanoid score	I2278
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.760