DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10175 and cest-2.3

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_506510.2	Gene:	cest-2.3 / 179918	WormBaseID:	WBGene00013873	Length:	665	Species:	Caenorhabditis elegans

Alignment Length:	582	Identity:	149/582 - (25%)
Similarity:	231/582 - (39%)	Gaps:	108/582 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 SLGKVRGRYQKYRSGERGGYYS--FKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCPHK 221
            |.|.:.|:.........|...:  |.|:.|..||.|..|||.....|.|.|:.:......:|  .
Worm    23 STGTIEGKILNATYSPFGNQTATVFLGIPYVEPPIGELRFRKPRLLKSWEGVLETKDYKPAC--M 85

  Fly   222 NMILDTFKG------DEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNSF----- 275
            :....|||.      .||||:.||||.|....:::..     ||:.:|||.....||::|
Worm    86 SYWRKTFKNGFVGEISEDCLYANVFTNQYCLQNKNCS-----VMIVVHGGRLVCESGSAFKPEIF 145

  Fly   276 ---LYGPDYLVAEDIVLVTLNYRLGPLGF-LTAGPDAPGNQGLKDQVLALKWVRDNIAAFGGDPN 336
               ..|.|    .:||:||.|||||..|| :..|.....|..:.|.:.|:||||..|..|||:.:
Worm   146 INNFVGQD----RNIVVVTFNYRLGVFGFGVFNGETGDTNVAMYDMLEAVKWVRKEIDQFGGNKD 206

  Fly   337 QVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSAS------SSQRAARLAANLG 395
            ::|:.|.||||..:.....|:.:|||.|:.|..| :.|...|.||:      .:|....:....|
Worm   207 RITMAGHSAGAGLIVDFTSSTLSKGLLHQQIVMS-APLQDISKSANFKGMTIVAQNVGCIPKEYG 270

  Fly   396 YVGANKTEDILDF--LRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEE 458
            :...:||:....:  |:...|..|:.|..:.     |:|:......|.|:|
Worm   271 FRKLSKTQINKTYLCLQNKSAQDLLHAQLSM-----QQNSTFYFGSPRVDG-------------- 316

  Fly   459 PFLTQHPSDMYHSQNFNS--DVAYMTGYNTHEA--MLFI---RRLRKNPQLLSIIENDFGRLVPQ 516
            .|:|.:|.:::   |||:  .:....|..|.|.  .|:|   :..|...|||..:....|
Worm   317 DFITDYPDNLF---NFNTIYPINTFIGTTTGELRDSLYITDPKNDRIKEQLLKNMCEHVG----- 373

  Fly   517 DLNVTESHDRVTREIRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRRTARNHAKFGNAPVYMYR 581
             ..:.|..:..|::..::|        ::..:...|..|:.|..|..:.|..| |..|:.|:||.
Worm   374 -YELFEKPEEFTKKCGNYY--------KNGTDAQFLSDDMEFYSGAIKVANAH-KRANSKVFMYS 428

  Fly   582 FSFDGSLGLYKRMLGIPRPGVCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRMVR-MWTNFAKYG 645
            :.:.|:...:.:.|..|.|.  |.::|.|.     |..|..|...:..|..|:.. |..||..:.
Worm   429 YDYKGAGTAFHKYLEAPSPH--HSEDLIYT-----FGTSRGPFVAKDYVIERIYSGMLANFINFE 486

  Fly   646 SPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFWDEMYQHYNGAAM 707
            .|:|..     |.:|...  |........:|...|..|            ..|..||...|:
Worm   487 DPSPSK-----TQQWRQY--TQEKREYFLIDFDKNFTM------------PGMKDHYYTRAL 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	145/568 (26%)
cest-2.3	NP_506510.2	Abhydrolase	20..532	CDD:389770	149/582 (26%)
cest-2.3	NP_506510.2	CemA	<550..>647	CDD:383495
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.000