Protein Alignment CG10175 and cest-2.2

DIOPT Version :10

• Sequence 1: NP_001287487.1
• Gene: CG10175 / 42773
• FlyBaseID: FBgn0039084
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_001256567.1
• Gene: cest-2.2 / 179917
• WormBaseID: WBGene00013874
• Length: 672
• Species: Caenorhabditis elegans
• Alignment Length: 593
• Identity: 147/593 - (24%)
• Similarity: 240/593 - (40%)
• Gaps: 102/593 - (17%)

  Fly   140 VVQEVVRSLRKEREIVATTSLGKVRGR-----YQKYRSGERGGYYSFKGMRYGAPPTGARRFRAA 199
            ::..:::::|..: :..::..|.:.||     |...  |.:.|...| |:.|..||.|..|||..
 Worm     7 ILWAILQNVRSTK-VKLSSRTGTIEGRTLTASYSPL--GNQTGIVFF-GVPYVEPPVGNLRFRKP 67

  Fly   200 EPEKPWSGIRDASREGQSCPHKNMILDTFKG------DEDCLFVNVFTTQMPKDDESAEQPKLPV 258
            .|.|||.|:.:|.....:|.....  .|:|.      .||||:.||||.|.     ..|.....|
 Worm    68 RPPKPWDGVLEAKEYKAACMSDQK--KTYKNGVGGPVSEDCLYANVFTNQY-----CLEHKNCSV 125

  Fly   259 MVWLHGGGFSFGSGNSFLYGPDYLV------AEDIVLVTLNYRLGPLGF-LTAGPDAPGNQGLKD 316
            |:.:|||.|...|.::  |.|:.::      ..:||:||.|||||..|. :..|.:...|.||.|
 Worm   126 MLTIHGGRFVIESASA--YDPEIIINNFVGQGRNIVVVTFNYRLGLFGLGMLNGDNQDTNFGLYD 188

  Fly   317 QVLALKWVRDNIAAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSA 381
            .:..::|.|..|..||||.:::|:.|.||||........|..:|||.|:.|..|.|..|   :|.
 Worm   189 ILEVVRWTRKEIKNFGGDKDRITMQGHSAGAVFTAAFSTSPLSKGLIHQQIIMSASMSN---LSK 250

  Fly   382 SSSQRAARLAANLGYVGANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPV----- 441
            .|:.:...:.|.:  ||....|.....|..|.    ||.|.|.:.::..:..:......:
 Worm   251 KSNVKELTVVARI--VGCLPDEHGFPKLSNVE----VEKAYTCLRSKSAQQILDAQLYMLRNTTY 309

  Fly   442 ------VEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAM--LFI---RR 495
                  ::|.:..|              :|.::| :.|....:..|.|..|.|.|  .:|   :.
 Worm   310 YIGQGHIDGIYQVD--------------YPDNLY-ATNSIYPINTMIGTTTAELMDSRYIVDPKN 359

  Fly   496 LRKNPQLLSIIENDFGRLVPQDLNVTESHDRVTREIRSFYLGSKHVGIESVDEMIALLTDLMFLQ 560
            ..|...||..:....|      ..:.:..:..:::.|:||        ::.::..:|..|:.|..
 Worm   360 TGKKEILLQNLCEHIG------YELYKEPEEFSQKCRNFY--------KNGEDAKSLGDDMEFYY 410

  Fly   561 GIRRTARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPGVCHGDELGYLFKFGFFNLSLDPKS 625
            |..:.|..|:. .:..|::|.|.:..:...||:......|.  ||::..|.|.....|.|.....
 Worm   411 GAIQLANVHSS-KDTNVFVYSFDYKEAGNAYKKYDKSLSPK--HGEDFAYAFGTNRGNFSTKDYV 472

  Fly   626 MEVQVKNRMVRMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDISANL---AMKTNP 687
            :|.....    |:.:|..:|.|:| .||    .:||...|..  .....:|...|.   .||.:.
 Worm   473 IEYIYSG----MFADFVNFGDPSP-LED----QEWAQYTPEK--REYFLIDFDKNFTMPGMKDHY 526

  Fly   688 EPERQRFW 695
            .|:...||
 Worm   527 YPKALEFW 534

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	155..695	CDD:395084	144/576 (25%)
cest-2.2	NP_001256567.1	alpha/beta hydrolases	25..534	CDD:473884	144/572 (25%)