DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10175 and ges-1

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_503411.1	Gene:	ges-1 / 178633	WormBaseID:	WBGene00001578	Length:	562	Species:	Caenorhabditis elegans

Alignment Length:	580	Identity:	163/580 - (28%)
Similarity:	271/580 - (46%)	Gaps:	92/580 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VATTSLGKVRG-RYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSC 218
            :..|:.|||.| .|:        |...|..:.:..||....||.......||..:..|::....|
Worm    19 IVETNYGKVEGIEYE--------GAEVFLAIPFAKPPVDDLRFEKPVAPDPWEDVYPATQYRNDC 75

  Fly   219 -PHKNMI--LDTFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNSFLYGPD 280
             ||..::  ..::.| ||||.:|:.   .||..|     ||||:.|:||||:..||.:.  :|.:
Worm    76 TPHYRLVAQFSSYSG-EDCLTLNII---KPKKAE-----KLPVLFWIHGGGYEIGSASQ--HGYE 129

  Fly   281 YL----VAEDIVLVTLNYRLGPLGFLTAG-PDAPGNQGLKDQVLALKWVRDNIAAFGGDPNQVTI 340
            :.    .::.:::.|:.||||.:||.:.| .|..||.||.||..||::|:.||..|||||||:||
Worm   130 FFAKRYASQGVIVATVQYRLGFMGFFSEGTSDVQGNWGLFDQAAALEFVKSNIENFGGDPNQITI 194

  Fly   341 FGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLG--YVGANKTE 403
            :|.||||:||..|.:|...:..:.:||..|.|:...|:...:..:.:.:||..||  :.||.
Worm   195 WGYSAGAASVSQLTMSPYTRDSYSKAIIMSASSFVGWATGPNVVETSKQLAEILGCPWPGAK--- 256

  Fly   404 DILDFLRRVPAMKLVEAAP----TTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQH 464
               :.:::....::.:|..    ||.|.:..|      :.||::|.:...:.||...|.|.   .
Worm   257 ---ECMKKKSLHEIFDAIEVQGWTTGTIDILR------WSPVIDGDFMTKNPEELIKESPV---K 309

  Fly   465 PSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDF-----GRLVPQDLNVTESH 524
            |:.:..|   |.:.:|....|....   |.....:|:.:..::.:|     ||.:..:....|:.
Worm   310 PTLIGMS---NKEGSYFAALNMGRV---IADFGLSPEDMPKVDEEFISEIIGRKLLYNNRYGENR 368

  Fly   525 DRVTREIRSFYLGS------KHVGIESVDEMIALLTDLMFLQGIRR--TARNHAKFGNAPVYMYR 581
            ::|..:|..||:..      |.:....||....||:|:.|...|.|  |:|...|   .||:.||
Worm   369 EKVWNDILDFYVKQGKPAEVKDLNGFYVDRYSELLSDITFNVPILREITSRVERK---TPVWTYR 430

  Fly   582 FS-FDGSLGLYKRMLGIPRPGVCHGDELGYLFK---FGFFNLSLDPKSMEVQVKNRMVRMWTNFA 642
            .. :|.:  ::|:.:.....|..|.:|..|||.   ....::..:|.|.   ::|.::.|..:||
Worm   431 MDHYDKN--IWKKHIPEQARGSPHANEYHYLFDMPVMAKIDMKKEPDSW---IQNDLIDMVISFA 490

  Fly   643 KYGSPTPDSEDPMLTTKWAPI-DPTNVMNSLNYMDI-SANLAMKTNPEPERQRFWDEMYQ 700
            |.|  .|..||    .:|.|: ||.:|    |:::| |..::::.....|...||:|:.|
Worm   491 KTG--VPQIED----VEWRPVSDPDDV----NFLNIRSDGVSIEHGLFQEPLAFWNELRQ 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	159/571 (28%)
ges-1	NP_503411.1	COesterase	18..535	CDD:278561	159/573 (28%)
ges-1	NP_503411.1	Aes	<100..>211	CDD:223730	52/117 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.820