DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10175 and Ces2c

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_598270.2	Gene:	Ces2c / 171118	RGDID:	621510	Length:	561	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	168/577 - (29%)
Similarity:	263/577 - (45%)	Gaps:	75/577 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 EREIVATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREG 215
            |...:.||..|:|||:....|. .:.|.::|.|:.:...|.|..||...|..:||||:||.:...
  Rat    31 ESSSIRTTHTGQVRGKLDHVRD-TKAGVHTFLGIPFAKAPVGPLRFAPPEDPEPWSGVRDGTSHP 94

  Fly   216 QSC------------PHKNMILDTFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFS 268
            ..|            ....|||.:....||||::|::|..     .:.|...|||||.:|||...
  Rat    95 AMCLQNIDMLDEVGLTDMKMILSSIPMSEDCLYLNIYTPA-----HAHEGSNLPVMVCIHGGALV 154

  Fly   269 FGSGNSFLYGPDYLVAEDIVLVTLNYRLGPLGFLTAGPD-APGNQGLKDQVLALKWVRDNIAAFG 332
            .|.. |...|....|.||:|:|.:.||||.|||.:.|.: |.||.|..|||.||:||:.|||.||
  Rat   155 IGMA-SMCDGSLLAVNEDLVVVAIQYRLGVLGFFSTGDEHARGNWGYLDQVAALRWVQQNIAHFG 218

  Fly   333 GDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYV 397
            |:||:|||||.|||.:||...::|..::||||.||.:||.||.| .:.:.:|:..:...|.|...
  Rat   219 GNPNRVTIFGVSAGGTSVSSHVISPMSQGLFHGAIMESGVALLP-DLISETSETVSTTVAKLSGC 282

  Fly   398 GANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLT 462
            .|..:|.::..||.....:::..           |.:......||:|              .||.
  Rat   283 EATDSETLVRCLRAKSGAEILVI-----------NKVFKMIPAVVDG--------------EFLP 322

  Fly   463 QHPSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQD-----LNVTE 522
            :||.::..|::|: .|..:.|.||.|....|..:....|::..:..:..:.|.:|     :...|
  Rat   323 RHPKELLASEDFH-PVPSIIGVNTDEYCCTIPMVMGTAQIIKELSRENLQAVLKDTAAQMMLPPE 386

  Fly   523 SHDRVTREIRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRRTARNHAKFGNAPVYMYRFSFDGS 587
            ..|.:..|    |:|:.........:...::.|.:|:....:.|  |.:..:||||.|.|....|
  Rat   387 CGDLLMEE----YMGNTDDPQTLQIQYAEMMGDFLFVIPALQVA--HFQRSHAPVYFYEFQHAPS 445

  Fly   588 LGLYKRMLGIPRPGVCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRMVRMWTNFAKYGSPTPDSE 652
               |.:.:..|.....|.||:.::|...|:.:.:|....|..:..||::.|.|||::|:|..:.
  Rat   446 ---YFKNVRPPHVKADHADEVPFVFGSFFWGIKVDFTEEEKLLSRRMMKYWANFARHGNPNSEG- 506

  Fly   653 DPMLTTKWAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFW----DEMYQHYNGA 705
                ...|..:|     :...|:.:....|:....:..|.:||    .:..|..|||
  Rat   507 ----LPYWPVLD-----HDEQYLQLDTQPAVDRALKARRLQFWTKTLPQKIQELNGA 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	161/555 (29%)
Ces2c	NP_598270.2	COesterase	32..540	CDD:395084	161/560 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910