Protein Alignment CG10175 and Ces3b

DIOPT Version :9

• Sequence 1: NP_001287487.1
• Gene: CG10175 / 42773
• FlyBaseID: FBgn0039084
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_653094.2
• Gene: Ces3b / 13909
• MGIID: 3644960
• Length: 571
• Species: Mus musculus
• Alignment Length: 666
• Identity: 184/666 - (27%)
• Similarity: 261/666 - (39%)
• Gaps: 189/666 - (28%)

  Fly   102 DMRQMAHMGSS-----TTETTAWKTLTSHPNSLVQLLPSRAMRVVQEVVRSLRKEREIVATTSLG 161
            :||.|...|||     |....|:.|..:.|            :|:|..|           .|.||
Mouse     3 NMRTMIPAGSSVLVWVTCLLLAFVTTVTGP------------KVIQPEV-----------DTPLG 44

  Fly   162 KVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCPH--KNMI 224
            :||||....:..:| ....|.|:.:...|.|..||.|..|.:||.|:||||.....|..  :.||
Mouse    45 RVRGRQVGVKDTDR-MVNVFLGIPFAQAPVGPLRFSAPLPPQPWEGVRDASINPPMCLQDVEKMI 108

  Fly   225 ---------LDTFKGDEDCLFVNVFT-TQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNS----- 274
                     :..|...||||.:|::: |::...|      |.|||||:|||....||..|
Mouse   109 NSRFGLNEKIKIFPISEDCLTLNIYSPTEITAGD------KRPVMVWIHGGSLLVGSSTSQDGSA 167

  Fly   275 -FLYGPDYLVAEDIVLVTLNYRLGPLGFLTAG-PDAPGNQGLKDQVLALKWVRDNIAAFGGDPNQ 337
             ..||       |:|:||:.||||..|||:.| ...|||:|..|.|.||:||:.|||.||||||.
Mouse   168 LAAYG-------DVVVVTVQYRLGIFGFLSTGDKHMPGNRGFLDVVAALRWVQGNIAPFGGDPNC 225

  Fly   338 VTIFGESAGASSVQLLLLSSQAKGLFHRAISQSG-------SALNPWSMSASSSQRAARLAANLG 395
            |||||.|||...|..|.||..:.|||||||||||       ..:.||.        .|:..||..
Mouse   226 VTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSGIVTTIMMEDMKPWP--------EAQNFANSV 282

  Fly   396 YVGANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPF 460
            ..|:....:::..|.:.....|:           ::.|:.:.::                ..:.|
Mouse   283 ACGSASPAELVQCLLQKEGKDLI-----------KQKNVNISYI----------------VNDSF 320

  Fly   461 LTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQDLNVTESHD 525
            ..|.|..:...|.|.: |.|:.|...||                     ||.|:.:.||:.:..:
Mouse   321 FPQRPEKLLADQQFPT-VPYLLGVTNHE---------------------FGWLLLKSLNILDKLE 363

  Fly   526 RVTR----EIRSFYLGSKHVGIE----SVDEMI--------------ALLTDLMFLQGIRRTARN 568
            .::|    ||...:|....|..|    .:||.:              .||.|:.|:    ....|
Mouse   364 HLSREDLLEISRPFLAIMEVPPEIMPTVIDEYLDNGSDQSATRYAFQELLGDISFI----IPTLN 424

  Fly   569 HAKF---GNAPVYMYRFSF-DGSLGLYKRMLGIPRPG---VCHGDELGYLFKFGFFNLSLDPKSM 626
            .:|:   ...||::|.|.. ..|...:|       |.   ..|..|..::|...|..   |..|:
Mouse   425 FSKYLRDAGCPVFLYEFQHTPSSFAKFK-------PAWVKADHASENSFVFGGPFLT---DESSL 479

  Fly   627 ---------EVQVKNRMVRMWTNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSL-NYMDISANL 681
                     |.|:...|:..|:.||:.|:|......|     |..      :|.| .|::|....
Mouse   480 LAFPEATEEEKQLSLTMMAQWSQFARTGNPNGKGLPP-----WPQ------LNQLEQYLEIGLES 533

  Fly   682 AMKTNPEPERQRFWDE 697
            ......:..|.:||.|
Mouse   534 RTGVKLKKGRLQFWTE 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	168/602 (28%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	170/617 (28%)
		Aes	75..>245	CDD:223730	78/182 (43%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910