DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10175 and Ces1c

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_031980.2	Gene:	Ces1c / 13884	MGIID:	95420	Length:	554	Species:	Mus musculus

Alignment Length:	580	Identity:	164/580 - (28%)
Similarity:	252/580 - (43%)	Gaps:	103/580 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCP 219
            |..|:.|||.|:|......|: ....|.|:.:..||.|:.||...:|.:|||.:::|:.....|.
Mouse    25 VVDTTQGKVLGKYISLEGFEQ-PVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNATSYPPMCS 88

  Fly   220 H----KNMILDTF---------KGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGS 271
            .    ..::.|.|         |..||||::|:::   |.|...:.|  ||||||:||||...|
Mouse    89 QDAGWAKILSDMFSTEKEILPLKISEDCLYLNIYS---PADLTKSSQ--LPVMVWIHGGGLVIG- 147

  Fly   272 GNSFLYGPDYLVAEDIVLVTLNYRLGPLGFLTAGPD-APGNQGLKDQVLALKWVRDNIAAFGGDP 335
            |.|...|......|::|:||:.||||..|..:.|.: :|||....||:.||:||:||||.|||:|
Mouse   148 GASPYNGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSPGNWAHLDQLAALRWVQDNIANFGGNP 212

  Fly   336 NQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYVGAN 400
            :.|||||||:|..||.:|:||...|.|||||||:||..:|. ::...:.|....:.|.|......
Mouse   213 DSVTIFGESSGGISVSVLVLSPLGKDLFHRAISESGVVINT-NVGKKNIQAVNEIIATLSQCNDT 276

  Fly   401 KTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEEPFLTQHP 465
            .:..::..||:....:|:|     |:.:..:.||.|.  .:::|.              .|.:.|
Mouse   277 SSAAMVQCLRQKTESELLE-----ISGKLVQYNISLS--TMIDGV--------------VLPKAP 320

  Fly   466 SDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQDLNVTESHDRVTRE 530
            .::...::||: |.|:.|:|..|                     ||.::|..|.......::..|
Mouse   321 EEILAEKSFNT-VPYIVGFNKQE---------------------FGWIIPMMLQNLLPEGKMNEE 363

  Fly   531 IRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRRTARNHA----KFGN----------------- 574
            ..|..|...|..:...:.||..:.: .:|:|:...|:...    .||:
Mouse   364 TASLLLRRFHSELNISESMIPAVIE-QYLRGVDDPAKKSELILDMFGDIFFGIPAVLLSRSLRDA 427

  Fly   575 -APVYMYRFSFDGSLGLYKRMLGIPRPGVCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRMVRMW 638
             ...|||.|.:..|....||...:...   ||||:  .|.||...|.......|..:...:::.|
Mouse   428 GVSTYMYEFRYRPSFVSDKRPQTVEGD---HGDEI--FFVFGAPLLKEGASEEETNLSKMVMKFW 487

  Fly   639 TNFAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFWDEM 698
            .|||:.|:|..:.     ...|...|...     .|:.|.|........:.|...||.|:
Mouse   488 ANFARNGNPNGEG-----LPHWPEYDEQE-----GYLQIGATTQQAQRLKAEEVAFWTEL 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	160/573 (28%)
Ces1c	NP_031980.2	Esterase_lipase	25..525	CDD:238191	160/566 (28%)
		Aes	<121..>234	CDD:223730	56/118 (47%)
		Prevents secretion from ER. /evidence=ECO:0000255	551..554
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810