DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10175 and Ces1g

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_067431.2	Gene:	Ces1g / 12623	MGIID:	88378	Length:	565	Species:	Mus musculus

Alignment Length:	618	Identity:	175/618 - (28%)
Similarity:	246/618 - (39%)	Gaps:	168/618 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   155 VATTSLGKVRGRYQKYRSGERGGYYS----FKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREG 215
            |..|..|||.|:|....     |:..    |.|:.:..||.|:.||...||.:|||.::..:...
Mouse    25 VVHTVHGKVLGKYVTLE-----GFSQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKHTTSYP 84

  Fly   216 QSC---------------------PHKNMILDTFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVM 259
            ..|                     ||        |..||||::|::|   |.|  ..:..:||||
Mouse    85 PLCYQNPEAALRLAELFTNQRKIIPH--------KFSEDCLYLNIYT---PAD--LTQNSRLPVM 136

  Fly   260 VWLHGGGFSFGSGNSFLYGPDYLVAEDIVLVTLNYRLGPLGFL-TAGPDAPGNQGLKDQVLALKW 323
            ||:||||... .|.|...|....|.|::|:|.:.||||..||. |....:.||.|..|||.||.|
Mouse   137 VWIHGGGLVI-DGASTYDGVPLAVHENVVVVVIQYRLGIWGFFSTEDEHSRGNWGHLDQVAALHW 200

  Fly   324 VRDNIAAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAA 388
            |:||||.|||:|..|||||||||..||.:|:||..||.||||||:||....||.....::...|.
Mouse   201 VQDNIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLFHRAIAQSSVIFNPCLFGRAARPLAK 265

  Fly   389 RLAANLG----------YVGANKTEDIL------------DFLRRVPAMKLVEAAPTTITAEDQR 431
            ::||..|          :....||||.|            |||                  .|.|
Mouse   266 KIAALAGCKTTTSAAMVHCLRQKTEDELLEVSLKMKFGTVDFL------------------GDPR 312

  Fly   432 NNIGLPFVP-VVEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFIRR 495
            .:  .||:| |::|.              .|.:.|.::...::||: |.||.|.|.||
Mouse   313 ES--YPFLPTVIDGV--------------LLPKAPEEILAEKSFNT-VPYMVGINKHE------- 353

  Fly   496 LRKNPQLLSIIENDFGRLVPQDLNVTESHDRVTREIRSF----------------------YLGS 538
                          ||.::|..|:...|..::.::..:.                      |||.
Mouse   354 --------------FGWIIPMFLDFPLSERKLDQKTAASILWQAYPILNISEKLIPAAIEKYLGG 404

  Fly   539 KHVGIESVDEMIALLTDLMFLQGIRR--TARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPG 601
            ........|..:.|:.|:||  |:..  .:|:|...| ||.|||.:.:..|      .:...||.
Mouse   405 TEDPATMTDLFLDLIGDIMF--GVPSVIVSRSHRDAG-APTYMYEYQYRPS------FVSDDRPQ 460

  Fly   602 VCHGDELGYLFK-FGFFNLSLDPKSMEVQVKNRMVRMWTNFAKYGSPTPDSEDPMLTTKWAPIDP 665
            ...||....||. :|...|.......|:.:...:::.|.|||:.|:|..:.     ...|...|.
Mouse   461 ELLGDHADELFSVWGAPFLKEGASEEEINLSKMVMKFWANFARNGNPNGEG-----LPHWPEYDQ 520

  Fly   666 TNVMNSLNYMDISANLAMKTNPEPERQRFWDEM 698
            ..     .|:.|..........:.:...||.|:
Mouse   521 KE-----GYLQIGVPAQAAHRLKDKEVDFWTEL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	171/611 (28%)
Ces1g	NP_067431.2	COesterase	24..545	CDD:278561	172/613 (28%)
Ces1g	NP_067431.2	Aes	<121..>239	CDD:223730	61/123 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.810