Protein Alignment CG10175 and CES1

DIOPT Version :9

• Sequence 1: NP_001287487.1
• Gene: CG10175 / 42773
• FlyBaseID: FBgn0039084
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 644
• Identity: 184/644 - (28%)
• Similarity: 277/644 - (43%)
• Gaps: 155/644 - (24%)

  Fly   111 SSTTETTAWKTLTSHPNSLVQLLPSRAMRVVQEVVRSLRKEREIVATTSLGKVRGRYQKYRSGER 175
            ::.:.:.||   ..||:|     |.                   |..|..|||.|::....
Human     9 ATLSASAAW---AGHPSS-----PP-------------------VVDTVHGKVLGKFVSLE---- 42

  Fly   176 GGYYS----FKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSC---PHKNMILD------- 226
             |:..    |.|:.:..||.|..||...:|.:|||.:::|:.....|   |....:|.
Human    43 -GFAQPVAIFLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRK 106

  Fly   227 ---TFKGDEDCLFVNVFTTQMPKDDESAEQPKLPVMVWLHGGGFSFGSGNSFLYGPDYLVAEDIV 288
               ..|..||||::|::|   |.|  ..::.:||||||:||||...|:.::: .|......|::|
Human   107 ENIPLKLSEDCLYLNIYT---PAD--LTKKNRLPVMVWIHGGGLMVGAASTY-DGLALAAHENVV 165

  Fly   289 LVTLNYRLGPLGFLTAGPD-APGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAGASSVQL 352
            :||:.||||..||.:.|.: :.||.|..|||.||:||:||||:|||:|..|||||||||..||.:
Human   166 VVTIQYRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSV 230

  Fly   353 LLLSSQAKGLFHRAISQSGSALNPWSMSASSSQRAARLAANLGYVGANKTED---ILDFLRRVPA 414
            |:||..||.|||||||:||.||....:....   ...||..:......||..   ::..||:...
Human   231 LVLSPLAKNLFHRAISESGVALTSVLVKKGD---VKPLAEQIAITAGCKTTTSAVMVHCLRQKTE 292

  Fly   415 MKLVEAAPTTITAEDQRNNIGLPFVPV-VEGYWNQDSQEEQ-----FYEEPFLTQHPSDMYHSQN 473
            .:|:|   ||:.         :.|:.: ::|    |.:|.|     ..:...|.:.|.::...:|
Human   293 EELLE---TTLK---------MKFLSLDLQG----DPRESQPLLGTVIDGMLLLKTPEELQAERN 341

  Fly   474 FNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIENDFGRLVPQDL---NVTESH-DRVTR----- 529
            |:: |.||.|.|..|                     ||.|:|..|   .::|.. |:.|.
Human   342 FHT-VPYMVGINKQE---------------------FGWLIPMQLMSYPLSEGQLDQKTAMSLLW 384

  Fly   530 --------------EIRSFYLGSKHVGIESVDEMIALLTDLMFLQGIRR--TARNHAKFGNAPVY 578
                          |....|||.....::..|..:.|:.|:||  |:..  .||||...| ||.|
Human   385 KSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDLIADVMF--GVPSVIVARNHRDAG-APTY 446

  Fly   579 MYRFSFDGSLG---LYKRMLGIPRPGVCHGDELGYLFKFGFFNLSLDPKSMEVQVKNRMVRMWTN 640
            ||.|.:..|..   ..|.::|      .|||||..:|...|  |.......|:::...:::.|.|
Human   447 MYEFQYRPSFSSDMKPKTVIG------DHGDELFSVFGAPF--LKEGASEEEIRLSKMVMKFWAN 503

  Fly   641 FAKYGSPTPDSEDPMLTTKWAPIDPTNVMNSLNYMDISANLAMKTNPEPERQRFWDEMY 699
            ||:.|:|..:.     ...|...:...     .|:.|.||.......:.:...||..::
Human   504 FARNGNPNGEG-----LPHWPEYNQKE-----GYLQIGANTQAAQKLKDKEVAFWTNLF 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	175/592 (30%)
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	176/614 (29%)
		Aes	<122..>240	CDD:223730	60/123 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	1	1.100	-	-	LDO	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.860