DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10175 and CEL

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001798.3	Gene:	CEL / 1056	HGNCID:	1848	Length:	753	Species:	Homo sapiens

Alignment Length:	559	Identity:	174/559 - (31%)
Similarity:	261/559 - (46%)	Gaps:	102/559 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   181 FKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREGQSCPHKNMILDTFKGDEDCLFVNVFTTQMP 245
            |||:.:.||   .:.....:|...|.|...|....:.|....:..|:..||||||::|::..|..
Human    50 FKGIPFAAP---TKALENPQPHPGWQGTLKAKNFKKRCLQATITQDSTYGDEDCLYLNIWVPQGR 111

  Fly   246 KDDESAEQPKLPVMVWLHGGGFSFGSG------NSFLY-GPDYLVAEDIVLVTLNYRLGPLGFLT 303
            |.    ....||||:|::||.|..|||      |::|| |.:.....::::||.|||:||||||:
Human   112 KQ----VSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRGNVIVVTFNYRVGPLGFLS 172

  Fly   304 AGPDA--PGNQGLKDQVLALKWVRDNIAAFGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRA 366
            .| ||  |||.||:||.:|:.||:.||||||||||.:|:||||||.:||.|..||...|||..||
Human   173 TG-DANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRA 236

  Fly   367 ISQSGSALNPWSMSASSSQRAARLAANLGY-VGANKTEDILDFLRRVPAMKLVEAAPTTITAEDQ 430
            |||||.||:||.:..:....|.::|..:|. ||        |..|....:|:.:....|:..:..
Human   237 ISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVG--------DAARMAQCLKVTDPRALTLAYKVP 293

  Fly   431 RNNIGLP------FVPVVEGYWNQDSQEEQFYEEPFLTQHPSDMYHSQNFNSDVAYMTGYNTHEA 489
            ...:..|      ||||::|              .|:...|.::|.:.   :|:.|:.|.|..:.
Human   294 LAGLEYPMLHYVGFVPVIDG--------------DFIPADPINLYANA---ADIDYIAGTNNMDG 341

  Fly   490 MLF----IRRLRKNPQLLSIIENDFGRLVPQDLNVTESHDRVTREIRSFYLGSK---HVGIESVD 547
            .:|    :..:.|..:  .:.|.||.:||        |...:|:.:|    |:|   .|..||..
Human   342 HIFASIDMPAINKGNK--KVTEEDFYKLV--------SEFTITKGLR----GAKTTFDVYTESWA 392

  Fly   548 E----------MIALLTDLMFLQGIR-RTARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRPG 601
            :          ::...||::||.... ..|::.|...:|..|.|.||....:.:|.:.:|..
Human   393 QDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLFSHPSRMPVYPKWVGAD--- 454

  Fly   602 VCHGDELGYLFKFGFFNLSLDPKSMEVQ---VKNRMVRMWTNFAKYGSPTPDSEDPMLTTKWAPI 663
              |.|::.|:|...|    ..|.....|   |...|:..||||||.|.  |:..|..:.|.|.|.
Human   455 --HADDIQYVFGKPF----ATPTGYRPQDRTVSKAMIAYWTNFAKTGD--PNMGDSAVPTHWEPY 511

  Fly   664 DPTNVMNSLNYMDISANL---AMKTNPEPERQRFWDEMY 699
            ...|    ..|::|:..:   :||.:......|:|...|
Human   512 TTEN----SGYLEITKKMGSSSMKRSLRTNFLRYWTLTY 546

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	172/553 (31%)
CEL	NP_001798.3	Heparin-binding	21..121		22/77 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100080
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720