DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10175 and bche

DIOPT Version :9

Sequence 1:	NP_001287487.1	Gene:	CG10175 / 42773	FlyBaseID:	FBgn0039084	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	XP_002931610.1	Gene:	bche / 100495889	XenbaseID:	XB-GENE-980117	Length:	602	Species:	Xenopus tropicalis

Alignment Length:	605	Identity:	180/605 - (29%)
Similarity:	274/605 - (45%)	Gaps:	135/605 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 EREIVATTSLGKVRGRYQKYRSGERGGYYSFKGMRYGAPPTGARRFRAAEPEKPWSGIRDASREG 215
            |.:|| .|..|||.|......||.   ..:|.|:.|..||.|..||:...|.||||.|.:||:.|
Frog    29 ETDIV-DTKYGKVTGVQISVFSGI---ITAFLGIPYAEPPIGDLRFKKPVPHKPWSEIWNASQYG 89

  Fly   216 QSCPHK-NMILDTFKG----------DEDCLFVNVF-TTQMPKDDESAEQPKLPVMVWLHGGGFS 268
            .||... :.|...|.|          .||||::|:: .|..|::        ..||||::||.|.
Frog    90 NSCYQTVDQIFPGFSGAEMWNPNTQLSEDCLYLNIWIPTPKPRN--------ASVMVWIYGGSFE 146

  Fly   269 FGSGNSFLYGPDYLV-AEDIVLVTLNYRLGPLGFLT--AGPDAPGNQGLKDQVLALKWVRDNIAA 330
            .|:.:..||...:|. .|.:::|::|||||.||||.  ...:||||.||.||.|||:||.:||||
Frog   147 TGTSSLDLYDGKFLARTERVIVVSMNYRLGALGFLAFPGNNEAPGNVGLFDQRLALQWVYENIAA 211

  Fly   331 FGGDPNQVTIFGESAGASSVQLLLLSSQAKGLFHRAISQSGSALNPWSM--SASSSQRAARLAAN 393
            |||:|..:||||||||.:||...:||.::.|.|.|||.||.:|..||::  .|.:|.||..||..
Frog   212 FGGNPKSITIFGESAGGASVSYHMLSPKSHGFFTRAIMQSATANAPWAVITKAEASNRALTLANL 276

  Fly   394 LGYVGANKTEDILDFLRRVPAMKLVEAAPTTITAEDQRNNIGLPFVPVVEGYWNQDSQEEQFYEE 458
            |.....|:|| |:..||.....::.|.|   ::....|:.|.:.|.|.|:|
Frog   277 LNCFYRNETE-IIACLRNKSPEEIFEKA---VSVLPHRSVIEVNFPPTVDG-------------- 323

  Fly   459 PFLTQHPSDMYHSQNFNSDVAYMTGYNTHEAMLFIRRLRKNPQLLSIIEND------------FG 511
            .||.:.|                      |.::.:.:|:|..|:|:.:..|            |.
Frog   324 DFLIEMP----------------------EILMQLGQLKKKTQILTGVNKDEGSYFLVYGLPGFS 366

  Fly   512 RLVPQDLNVTESHDRVTREIRSFYLGSKHVGIESV-----------------DEMIALLTDLMFL 559
            :.....:|.|:.|    :.::..:..:..:.|:||                 |.|..::.|..|:
Frog   367 KDHESFINRTQFH----KSVKLAFPKATELAIDSVLFHYTNWEDEQNPSHNRDAMDDIVGDYNFI 427

  Fly   560 QGIRRTARNHAKFGNAPVYMYRFSFDGSLGLYKRMLGIPRP---GVCHGDELGYLFKFGFFNLSL 621
            ..:....:.:::.|| ..|:|.|        :.|...:..|   ||.||.|:.::|....:. .|
Frog   428 CPLLEFTKWNSELGN-NAYLYYF--------HHRSSKLTWPGWMGVMHGYEIEFVFGIPMYR-RL 482

  Fly   622 DPKSMEVQVKNRMVRMWTNFAKYGSP--TPDSEDPMLTTKWAPIDPTNVMNSLNYM-----DISA 679
            :....|..:...::|.|.||||.|:|  ...||:     :|    |...::..:|:     |...
Frog   483 NYTKAEETLSRTLMRYWANFAKTGNPNGAQSSEN-----RW----PVFTLDEQHYLMLGTEDSKT 538

  Fly   680 NLAMKTNPEPERQRFWDEMY 699
            |..|:.    ::.|||:..|
Frog   539 NRKMRA----KQCRFWNNFY 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10175	NP_001287487.1	COesterase	157..695	CDD:278561	174/593 (29%)
bche	XP_002931610.1	COesterase	32..550	CDD:365897	176/596 (30%)
bche	XP_002931610.1	AChE_tetra	565..599	CDD:370053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010